Results 221 to 230 of about 2,795,372 (389)

Antiviral Compounds Discovered by Virtual Screening of Small−Molecule Libraries against Dengue Virus E Protein [PDF]

, 2008
Zhigang Zhou, Mansoora Khaliq, Jae-Eun Suk, Chinmay G. Patkar, Long Li, Richard Kühn, Carol Beth Post   +6 more
openalex   +1 more source

PSMD14 Stabilizes SLC7A11 to Ameliorate Glucocorticoid‐Induced Osteoporosis by Suppressing Osteocyte Ferroptosis

Advanced Science, EarlyView.
Glucocorticoid‐induced osteoporosis (GIOP) triggers osteocyte ferroptosis via SLC7A11 degradation. PSMD14 stabilizes SLC7A11 by counteracting glucocorticoid‐driven ubiquitination, preserving cystine uptake and glutathione synthesis. AAV‐mediated PSMD14 delivery or its agonist Pantethine rescues osteocyte survival and bone loss in GIOP mice.
Yifeng Shi, Qian Tang, Sunren Sheng, Hongyi Jiang, Chen Jin, Chencheng Zhou, Chenglong Xie, Lin Zheng, Di Zhang, Hui Xu, Cong Xu, Haiwei Ma, Guangheng Xiang, Wenfei Ni, Xiaoyun Pan, Lei Yang, Huazi Xu, Yu Qian, Aimin Wu, Xiangyang Wang, Gang Zheng   +20 more
wiley   +1 more source

Identification of chemical scaffolds for targeting ubiquitin-specific protease 11 (USP11) through high-throughput virtual screening. [PDF]

J Enzyme Inhib Med Chem
Lee H, Hurh S, Kang S, Yoon J, Hwang JI, Logan DT, Kim HR.   +6 more
europepmc   +1 more source

Virtual Screening: A Fast Tool for Drug Design [PDF]

, 2008
Vivek K. Vyas
openalex   +1 more source

Advances in Single‐Cell Sequencing for Infectious Diseases: Progress and Perspectives

Advanced Science, EarlyView.
Single‐cell sequencing technologies uncover novel, unknown, and emergent features of many diseases. This review describes recent progress of single‐cell sequencing technologies and their applications in infectious diseases, summarizes the underlying commonalities of different infections and discusses future research directions, facilitating the ...
Mengyuan Lyu, Yang Liu, Jian Zhou, Hongli Lai, Hongxia Ruan, Dongsheng Wu, Shun Zhu, Xudong Zhou, Wananqi Ma, Yuchen Huang, Shuting Lei, Han Luo, Jie Chen, Binwu Ying   +13 more
wiley   +1 more source

A High‐Fidelity RNA‐Targeting Cas13X Downregulates Connexin43 in Macroglia: A Novel Neuroprotective Strategy for Glaucoma

Advanced Science, EarlyView.
This study highlights the role of connexin43 (Cx43) in mediating glia activation and neuroinflammation in glaucoma. Using Cx43 knockout mice, it is shown that macroglial cells‐derived Cx43 modulates microglial activation, proliferation, migration, and polarization.
Guoli Zhao, Zhen Li, Ming‐Jie Zhao, Shu‐Ying Li, Qing Xia, Shuoyu Xu, Yu Zhang, Yi Wang, Fang Li, Yu‐Ling Liu, Yun‐Hui Guo, Ruo‐Xi Xu, Han Zhou, Hong Zhou, Wen‐Wen Ding, Yong‐Chen Wang, Yanying Miao, Zhongfeng Wang   +17 more
wiley   +1 more source

Virtual screening for novel COX-2 inhibitors using the ZINC database [PDF]

, 2008
Kotaprolu Naga Sudha, Mohammed Shakira, Paturi Prasanthi, Nalla Sarika, Ch Narasimha Kumar, Padavala Ajay Babu   +5 more
openalex   +1 more source

Virtual Screening and Molecular Dynamics of Cytokine-Drug Complexes for Atherosclerosis Therapy. [PDF]

Int J Mol Sci
Rodríguez-Fernández MA, Tristán-Flores FE, Casique-Aguirre D, Negrete-Rodríguez MLX, Cervantes-Montelongo JA, Conde-Barajas E, Acosta-García G, Silva-Martínez GA.   +7 more
europepmc   +1 more source

A Novel Automated Lazy Learning QSAR (ALL-QSAR) Approach:  Method Development, Applications, and Virtual Screening of Chemical Databases Using Validated ALL-QSAR Models

, 2006
Shuxing Zhang, Alexander Golbraikh, Scott Oloff, Harold Kohn, Alexander Tropsha   +4 more
openalex   +2 more sources

Hierarchical Structure-Based Virtual Screening for Drug Design [PDF]

, 2008
Maria A. Miteva
openalex   +1 more source