Results 241 to 250 of about 2,795,372 (389)

Identification of non-lipid LPA3 antagonists by virtual screening [PDF]

, 2008
James I. Fells, Ryoko Tsukahara, Yuko Fujiwara, Jianxiong Liu, Donna Perygin, Daniel A. Osborne, Gábor Tigyi, Abby L. Parrill   +7 more
openalex   +1 more source

Dual‐Energy CT‐Based Assessment of Thrombotic Heterogeneity for Predicting Stroke Source and Response to Machine Thrombectomy: A Step Toward Visualization Thrombus Treatment

Advanced Science, EarlyView.
The research indicates that dual energy CT scanning can accurately predict the stroke source and clinical outcomes by analyzing thrombus heterogeneity. Based on histopathological analysis of thrombus components, these scans are better able to display thrombus details than standard CT scans, which is helpful for the development of visual navigation ...
Jingxuan Jiang, Sijia Wang, Fan Xiao, Hongmei Gu, Mingkang Wang, Hao Tian, Baohui Guan, Kai Sheng, Yijia Xiong, Huilin Zhao, Minda Li, Li Xu, Zheng Sun, Haiyan Du, Wenxian Du, Yuehua Li   +15 more
wiley   +1 more source

UMAP-based clustering split for rigorous evaluation of AI models for virtual screening on cancer cell lines. [PDF]

J Cheminform
Guo Q, Hernandez-Hernandez S, Ballester PJ.   +2 more
europepmc   +1 more source

Recent Advances in mRNA Delivery Systems for Cancer Therapy

Advanced Science, EarlyView.
This review systematically investigates the applications of mRNA therapy in cancer treatment, with particular emphasis on nonviral delivery systems, targeting strategies, stimulus‐responsive systems, and local delivery methods. Concluding with a meticulous evaluation, the review sheds light on the prevailing challenges while illuminating promising ...
Zheng Zhang, Ya‐Nan Fan, Si‐Qi Jiang, Ya‐Jing Ma, Yao‐Ru Yu, Yu‐Xin Qing, Qian‐Ru Li, Yi‐Lin Liu, Song Shen, Jun Wang   +9 more
wiley   +1 more source

Leveraging AlphaFold2 structural space exploration for generating drug target structures in structure-based virtual screening. [PDF]

Biochem Biophys Rep
Uchikawa K, Furui K, Ohue M.
europepmc   +1 more source

Discovery of Human Macrophage Migration Inhibitory Factor (MIF)-CD74 Antagonists via Virtual Screening [PDF]

, 2008
Zoe Cournia, Lin Leng, Sunilkumar Gandavadi, Xin Du, Richard Bucala, William L. Jorgensen   +5 more
openalex   +1 more source

Identifying Myeloid‐Derived Suppressor Cells and Lipocalin‐2 as Therapeutic Targets for Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Inflammatory dysregulation drives intervertebral disc degeneration via stage‐dependent immune cellular dynamics. Single‐cell transcriptomics and genetic risk mapping revealed a shift from LCN2high myeloid‐derived suppressor cells maintaining disc repair in early stages to IL1B+ macrophage‐dominated pathology in advanced disease.
Changmeng Zhang, Haoyun Li, Hongfei Wang, Liangyu Shi, Ying Shing Chan, Yu Wang, Graham Ka Hon Shea   +6 more
wiley   +1 more source

Retraction: Structure-based virtual screening of Trachyspermum ammi metabolites targeting acetylcholinesterase for Alzheimer's disease treatment. [PDF]

PLoS One
PLOS One Editors.
europepmc   +1 more source

DOVIS 2.0: an efficient and easy to use parallel virtual screening tool based on AutoDock 4.0 [PDF]

, 2008
Xiaohui Jiang, Kamal Kumar, Xin Hu, Anders Wallqvist, Jaques Reifman   +4 more
openalex   +1 more source

Resolving Artifacts in Voltage‐Clamp Experiments with Computational Modeling: An Application to Fast Sodium Current Recordings

Advanced Science, EarlyView.
Patch‐clamp experiments are fundamental to the measurement and understanding of ion currents that underlie physiological functions from neural activity to muscle contraction. Via a mathematical model of the experimental apparatus, this article highlights how artifact effects can be as large as some reported mutation and drug effects, and enables ...
Chon Lok Lei, Alexander P. Clark, Michael Clerx, Siyu Wei, Meye Bloothooft, Teun P. de Boer, David J. Christini, Trine Krogh‐Madsen, Gary R. Mirams   +8 more
wiley   +1 more source