Results 271 to 280 of about 2,795,372 (389)

A Dynamic Contrast‐Enhanced MRI‐Based Vision Transformer Model for Distinguishing HER2‐Zero, ‐Low, and ‐Positive Expression in Breast Cancer and Exploring Model Interpretability

Advanced Science, EarlyView.
This study develops a Vision Transformer‐based DCE‐MRI model for the non‐invasive classification of HER2 expression in breast cancer, demonstrating robust performance across multicenter cohorts. By integrating transcriptomic analysis, the model reveals immune‐related pathway differences among distinct HER2 expression levels.
Xu Zhang, Yi‐Yuan Shen, Guan‐Hua Su, Yuan Guo, Ren‐Cheng Zheng, Si‐Yao Du, Si‐Yi Chen, Yi Xiao, Zhi‐Ming Shao, Li‐Na Zhang, He Wang, Yi‐Zhou Jiang, Ya‐Jia Gu, Chao You   +13 more
wiley   +1 more source

GPCRVS - AI-driven Decision Support System for GPCR Virtual Screening. [PDF]

Int J Mol Sci
Latek D, Prajapati K, Dragan P, Merski M, Osial P.   +4 more
europepmc   +1 more source

PlantGPT: An Arabidopsis‐Based Intelligent Agent that Answers Questions about Plant Functional Genomics

Advanced Science, EarlyView.
PlantGPT integrates 60 000+ plant research articles with Arabidopsis phenotype‐gene data through retrieval‐augmented generation and fine‐tuning of Llama3‐8B. This open‐source, specialized AI system outperforms general large language models in plant gene‐phenotype relationships, establishing a new paradigm for functional genomics research and molecular ...
Ruixiang Zhang, Yu Wang, Weiyang Yang, Jun Wen, Weizhi Liu, Shipeng Zhi, Guangzhou Li, Nan Chai, Jiaqi Huang, Yongyao Xie, Xianrong Xie, Letian Chen, Miao Gu, Yao‐Guang Liu, Qinlong Zhu   +14 more
wiley   +1 more source

Discovery of natural scaffolds as HER2 inhibitors for breast cancer: virtual screening, molecular dynamics, and biological characterization with selectivity profiling. [PDF]

Sci Rep
Hossam A, Abdallah II, El-Sebakhy NA, Alnajjar R, Mohyeldin MM.   +4 more
europepmc   +1 more source

Shifting Acetylene Hydrochlorination From the Gas to the Liquid Phase: Vinyl Chloride Production in Bichloride‐Based Ionic Liquids

Advanced Science, EarlyView.
Combining the bichloride‐based ionic liquid [NEt3Me][Cl(HCl)n] with PdCl2 results in the formation of the highly active, mercury‐free catalyst [NEt3Me]2[PdCl4] for acetylene hydrochlorination to vinyl chloride. Replacing HCl with the bichloride improves the process safety and achieves a competitive turnover frequency of 110 molVCM h−1 molPdCl2−1.
Gesa H. Dreyhsig, Vera Giulimondi, Merlin Kleoff, Letizia Lanfredi, Maxim Fuchs, Niklas Limberg, Marc Reimann, Martin Kaupp, Javier Pérez‐Ramírez, Sebastian Riedel   +9 more
wiley   +1 more source

Drug Repurposing by Virtual Screening: Identification of New Already Approved ROCK Inhibitors as Promising Drugs to Target Neurodegeneration. [PDF]

ACS Omega
Silva Franco L, Rodrigues DA, Baumart GJ, de Jesus BDSM, Gomes FCA, Lima LM, Fraga CAM, Pinheiro PSM.   +7 more
europepmc   +1 more source

Sleep Deprivation Activates a Conserved Lactate‐H3K18la‐RORα Axis Driving Neutrophilic Inflammation Across Species

Advanced Science, EarlyView.
Sleep deprivation triggers systemic immune activation characterized by neutrophil accumulation and cytokine release. This study reveals a conserved metabolic‒epigenetic mechanism whereby lactate‐induced H3K18 lactylation upregulates RORα expression, promoting neutrophilic inflammation.
Ren Zhou, Keyun Li, Xiezong Hu, Shuhao Fan, Yuxuan Gao, Xiaoshu Xue, Yu Bu, Haoyi Zhang, Yili Wang, Chunjiao Wei, Shangrong Zhang, Zhongwen Xie, Chao Liu, Peng Chen, Zongjun Yin, Dalong Ren   +15 more
wiley   +1 more source

Discovery of Novel Inhibitors of <i>Aspergillus fumigatus</i> DHODH via Virtual Screening, MD Simulation, and In Vitro Activity Assay. [PDF]

Molecules
Li K, Xia W, Zhang JZH.
europepmc   +1 more source

A Wearable AI‐Driven Mask with Humidity‐Sensing Respiratory Microphone for Non‐Vocal Communication

Advanced Science, EarlyView.
A wearable, plug‐and‐play respiratory microphone—featuring a gold nanoparticle‐based humidity sensor—facilitates voice‐free verbal communication for patients with impaired vocal fold function. Abstract Hoarseness and dysphonia caused by vocal cord conditions or laryngeal surgeries significantly hinder communication and quality of life.
Jianfei Wang, Hongyu Zhang, Xiaomin Wu, Mingyan Gao, He Wen, Zhibo Zhang, Kremena Makasheva, Wen Jung Li, Zuobin Wang   +8 more
wiley   +1 more source

Identification of a Non-Retinoid Opsin Ligand Through Pharmacophore-Guided Virtual Screening-A Novel Potential Rhodopsin-Stabilizing Compound. [PDF]

Molecules
Di Stefano M, Ghilardi M, Poles C, Piazza L, Demontis GC, Poli G, Tuccinardi T, Macchia M.   +7 more
europepmc   +1 more source