Results 281 to 290 of about 2,795,372 (389)

Exosomal CMTM4 Induces Immunosuppressive Macrophages to Promote Ovarian Cancer Progression and Attenuate Anti‐PD‐1 Immunotherapy

Advanced Science, EarlyView.
In ovarian tumors with high CMTM4 expression, exosomes transfer CMTM4 to macrophages, upregulating ICAM1 and promoting M2 polarization via p65 nuclear translocation. This suppresses immunity by increasing PD‐1 and Tregs while reducing CD8+ T cells.
Bo Yin, Jianyi Ding, Jie Liu, Haoran Hu, Yashi Zhu, Meiqin Yang, Huijuan Zhou, Baoyou Huang, Tiefeng Huang, Mengjie Li, Yinyan He, Ang Li, Lingfei Han   +12 more
wiley   +1 more source

Identification of Food-Derived Electrophilic Chalcones as Nrf2 Activators Using Comprehensive Virtual Screening Techniques. [PDF]

Antioxidants (Basel)
Bai B, Tu P, Weng J, Zhang Y, Lin Q, Muskat MN, Wang J, Tang X, Cheng X.   +8 more
europepmc   +1 more source

Ensemble-Based Virtual Screening Reveals Potential Novel Antiviral Compounds for Avian Influenza Neuraminidase

, 2008
Lily S. Cheng, Rommie E. Amaro, Dong Xu, Wilfred W. Li, Peter Arzberger, J. Andrew McCammon   +5 more
openalex   +1 more source

KRAS/ABHD17C/ALOX15B Axis Promotes Pancreatic Cancer Progression via Ferroptosis Evasion

Advanced Science, EarlyView.
Phosphorylation of ABHD17C induced by KRASmut/ERK signaling facilitates ALOX15B depalmitoylation and degradation via the CUL4/DDB1/DCAF10 complex, thereby enabling KRASmut‐PDAC cell to evade ferroptosis. Methyl protodioscin inhibits KRASmut‐PDAC progression by disrupting the ABHD17C/ALOX15B interaction and inducing ferroptosis, which represents a ...
Man Li, Xuexin Yu, Yuanji Liu, Shuqin Ouyang, Long Wu, Xiaohong Chen, Huiqi Yu, Haoming Chen, Senmao Lian, Ziwen Li, Liyun Gong, Libing Song, Jun Li   +12 more
wiley   +1 more source

Discovery of natural CdnP inhibitors through structure-based virtual screening and molecular dynamics simulations. [PDF]

Microbiol Spectr
Gu X, Xiong C, Wang X, Zhu H, Sun W, He Y, Zhang J.   +6 more
europepmc   +1 more source

Dedifferentiation and Transfer in Executive Function and Math Ability Following a Five‐Year Abacus Training in Schoolchildren

Advanced Science, EarlyView.
While cognitive development typically exhibits differentiation, marked by decreasing inter‐domain correlations, this study demonstrates that five‐year abacus training is associated with de‐differentiation of executive function and mathematical ability in school‐aged children.
Tianyong Xu, Xinyang Liu, Hongjian He, Changsong Zhou, Andrea Hildebrandt, Feiyan Chen   +5 more
wiley   +1 more source

Graph convolutional neural networks improved target-specific scoring functions for cGAS and kRAS in virtual screening. [PDF]

Comput Struct Biotechnol J
Wang B, Junaid M, Li W.
europepmc   +1 more source

Probing Anisotropic Quasiparticle Dynamics and Topological Phase Transitions in Quasi‐1D Topological Insulator ZrTe5

Advanced Science, EarlyView.
This study reveals quasiparticle dynamics in ZrTe5. Polarization‐dependent measurements show transient reflectivity anisotropy arises from electron relaxation and lattice vibrations. The first dynamical evidence of a temperature‐induced Lifshitz transition is reported.
Yueying Hou, Linze Li, Sutao Sun, Gan Liu, Hongyuan Zhao, Zhiheng Chen, Xuejun Yan, Yang‐Yang Lv, Yurong Yang, Shu‐Hua Yao, Jian Zhou, Y.B. Chen, Ming‐Hui Lu, Vitalyi Gusev, Yan‐Feng Chen   +14 more
wiley   +1 more source

Identification of novel TMEM16A blockers through integrated virtual screening, molecular dynamics, and experimental studies. [PDF]

Sci Rep
Sangkhawasi M, Pitaktrakul W, Khumjiang R, Shigeta Y, Muanprasat C, Hengphasatporn K, Rungrotmongkol T.   +6 more
europepmc   +1 more source