Results 291 to 300 of about 2,795,372 (389)

Hierarchical Prediction and Perturbation of Chromatin Organization Reveal How Loop Domains Mediate Higher‐Order Architectures

Advanced Science, EarlyView.
HiCGen introduces a hierarchical deep learning framework to predict genome organization across spatial scales using DNA sequences and genomic features. The model enables cross‐cell‐type predictions and in silico perturbation analysis, revealing correlations between loop domains and higher‐order structures.
Jiachen Wei, Yue Xue, Yi Qin Gao
wiley   +1 more source

Discovery of Potential Scaffolds for Methionine Adenosyltransferase 2A (MAT2A) Inhibitors: Virtual Screening, Synthesis, and Biological Evaluation. [PDF]

Molecules
Qi C, Yu X, Zuo S, Han P, An R, Zhang Y.
europepmc   +1 more source

Immunocompatible Elastomer With Enhanced Fibrous Capsule‐Resistance and Elasticity by Water‐Induced Surface Phase Reconfiguration.

Advanced Science, EarlyView.
This study introduces a strategy for engineering heterogeneous surface and bulk structures within a single material, termed phase‐separation and underwater reconfiguration‐enhanced (PURE) elastomers. These elastomers combine high bulk elasticity with enhanced immunocompatibility at the surface.
Xianchi Zhou, Wenzhong Cao, Weifeng Liu, Wenbin Dai, Zihao Zhu, Fan Jia, Haijie Han, Ke Yao, Youxiang Wang, Jian Ji, Peng Zhang   +10 more
wiley   +1 more source

Uncovering leading compounds for alzheimer's disease treatment: mendelian randomization and virtual screening insights into plasma protein modulation. [PDF]

Biol Res
Sun X, Hu X, Wei J, An H.
europepmc   +1 more source

An Amygdala‐hippocampus Circuit for Endocannabinoid Modulation of Anxiety Avoidance

Advanced Science, EarlyView.
This study employs three synapse‐specific endocannabinoids (eCB) probes to monitor dynamic eCB release, activate CB1Rs and knockdown 2‐AG biosynthesis enzymes in glutamatergic anterior basolateral amygdala ‐ ventral hippocampus (aBLA–vHPC) circuit. At aBLA–vHPC circuits, activation of CB1Rs reduce anxiety avoidance, and knockdown of eCB biosynthesis ...
Bao Xue, Mao‐Xing Zhang, Xiao‐Chen Bi, Shou‐Peng Lai, Xin‐Tian Bie, Yuan Dong, Jian‐Feng Li, Fang Gao, Xia Zhang, Ying Wang   +9 more
wiley   +1 more source

Discovery, Biological Evaluation and Binding Mode Investigation of Novel Butyrylcholinesterase Inhibitors Through Hybrid Virtual Screening. [PDF]

Molecules
Li L, Zhao P, Yang C, Yin Q, Wang N, Liu Y, Li Y.   +6 more
europepmc   +1 more source

Transparent and Transient Flexible Electronics

Advanced Science, EarlyView.
Transparent electronics has gained tremendous attention in recent years because of the growing demand for see‐through devices in applications such as displays, windscreens, and wearables. This review discusses the recent developments related to transparent electronics as well as the challenges associated with the development of flexible and transient ...
Nitheesh M. Nair, Ayoub Zumeit, Ravinder Dahiya   +2 more
wiley   +1 more source

Structure-Based Discovery of Orthosteric Non-Peptide GLP-1R Agonists via Integrated Virtual Screening and Molecular Dynamics. [PDF]

Int J Mol Sci
Alturki MS, Alkhodier RA, Gomaa MS, Hussein DA, Tawfeeq N, Al Khzem AH, Pottoo FH, Albugami SA, Aldawsari MF, Rants'o TA.   +9 more
europepmc   +1 more source

Integrating Statistical Predictions and Experimental Verifications for Enhancing Protein-Chemical Interaction Predictions in Virtual Screening

, 2009
Nobuyoshi Nagamine, Takayuki Shirakawa, Yusuke Minato, Kentaro Torii, Hiroki Kobayashi, Masaya Imoto, Yasubumi Sakakibara   +6 more
openalex   +2 more sources