Results 101 to 110 of about 149 (148)
Bilirubin Targeting WNK1 to Alleviate NLRP3‐Mediated Neuroinflammation
Advanced Science, EarlyView.At physiological concentrations, bilirubin binds to the kinase domain of WNK1, thereby augmenting its activity and facilitating the phosphorylation of downstream SPAK/OSR1. This phosphorylation inhibits KCC2 activity, leading to elevate intracellular chloride levels in neurons.
Linfei Mao +14 more
wiley +1 more source
A 3D Genome Atlas of Genetic Variants and Their Pathological Effects in Cancer
Advanced Science, EarlyView.The hierarchical organization of the eukaryotic genome is vital for nuclear function, and disruptions from genetic mutations can alter this 3D architecture. Cataloging thousands of interchromosomal translocations, structural variants, and single nucleotide polymorphisms, their impact on 3D genome organization is revealed. The scoring algorithm, 3DFunc,
Li Tang +6 more
wiley +1 more source
Elastic Relaxation of Coherent InGaN/GaN Interfaces at the Microwire LED Sidewall
Advanced Science, EarlyView.Strain mapping and modeling reveal that the interfacial shear stresses arise toward the traction free sidewall of microscale light emitting diode (LED) wires while the two complementary strained InGaN and GaN layers in multiple quantum wells are relaxed to revert their bulk lattice parameters near the sidewall.
Jongil Kim +5 more
wiley +1 more source
A Multi‐Objective Molecular Generation Method Based on Pareto Algorithm and Monte Carlo Tree Search
Advanced Science, EarlyView.Pareto Monte Carlo Tree Search Molecular Generation (PMMG), a molecular generation approach leveraging Monte Carlo Tree Search (MCTS) and Pareto algorithm, efficiently explores the Pareto front in high‐dimensional objective spaces for multi‐objective drug design.
Yifei Liu +12 more
wiley +1 more source
RFWD3 Reprograms Nucleotide Metabolism Through PHGDH to Induce Chemoresistance In Osteosarcoma
Advanced Science, EarlyView.RFWD3 is identified as a key regulator of cisplatin (DDP) sensitivity in osteosarcoma using a genome‐wide CRISPR screen. RFWD3 promotes PHGDH ubiquitination, enhancing NAD+‐mediated nucleotide biosynthesis. Knocking out RFWD3 sensitized osteosarcoma cells to DDP.
Wenchao Zhang +6 more
wiley +1 more source
Advanced Science, EarlyView.The multimodal AI‐based RSA model is a powerful tool for diagnosing GC‐CY1, offering significant advantages over traditional diagnostic methods. By combining radiomic and clinical data, the model achieves superior predictive performance, providing a non‐invasive, accurate, and rapid alternative for detecting peritoneal involvement in gastric cancer ...
Ping'an Ding +15 more
wiley +1 more source
Shared and Unique Neural Codes for Biological Motion Perception in Humans and Macaque Monkeys
Advanced Science, EarlyView.Cross‐species fMRI studies reveal distinct neural mechanisms for biological motion (BM) processing. In humans, the posterior superior temporal sulcus (hpSTS) selectively responds to conspecific BM, while monkeys process BM from both species in the middle temporal area (MT).
Yuhui Cheng +7 more
wiley +1 more source
Berberine is a Novel Mitochondrial Calcium Uniporter Inhibitor that Disrupts MCU‐EMRE Assembly
Advanced Science, EarlyView.Berberine, a safe and FDA‐approved drug, is identified as a novel mitochondrial calcium uniporter (MCU) inhibitor. By disrupting MCU‐EMRE interaction, Berberine prevents mitochondrial calcium overload and protects against ischemia/reperfusion injury, offering a promising therapeutic strategy for diseases linked to mitochondrial calcium dysregulation ...
Haixin Zhao +17 more
wiley +1 more source
Advanced Science, EarlyView.Graphic illustration showing the strategic approaches based on the currently investigated evidence of psychedelics that suggests the challenges and how to address the prescription of mental disorders. These applicable avenues may provide substantial insight into distinguishing between brain networks and psychedelics.
Sung‐Hyun Kim +5 more
wiley +1 more source