Results 251 to 260 of about 460,421 (314)

Virtual twins for model-informed precision dosing of clozapine in patients with treatment-resistant schizophrenia. [PDF]

CPT Pharmacometrics Syst Pharmacol
Mostafa S, Rafizadeh R, Polasek TM, Bousman CA, Rostami-Hodjegan A, Stowe R, Carrion P, Sheffield LJ, Kirkpatrick CMJ.   +8 more
europepmc   +1 more source

Rural-Urban Disparities in Video Telehealth Use During Rapid Mental Health Care Virtualization Among American Indian/Alaska Native Veterans.

JAMA Psychiatry, 2023
Kusters IS, Amspoker AB, Frosio K, Day SC, Day G, Ecker A, Hogan J, Lindsay JA, Shore J.   +8 more
europepmc   +1 more source

High Sugar Induced RCC2 Lactylation Drives Breast Cancer Tumorigenicity Through Upregulating MAD2L1

Advanced Science, EarlyView.
This study finds that KAT2A mediates the lactylation modification of the non‐histone protein RCC2 at K124, facilitating the recruitment of free SERBP1 and aiding in the formation of the initial SERBP1‐MAD2L1 complex. SERBP1 enhances the stability of MAD2L1 mRNA and promotes cellular proliferation.
Bowen Zheng, Yunhao Pan, Fengyuan Qian, Diya Liu, Danrong Ye, Bolin Yu, Seng Zhong, Wenfang Zheng, Xuehui Wang, Baian Zhou, Yuying Wang, Lin Fang   +11 more
wiley   +1 more source

Identification and Biological Evaluation of a Novel CLK4 Inhibitor Targeting Alternative Splicing in Pancreatic Cancer Using Structure‐Based Virtual Screening

Advanced Science, EarlyView.
Pancreatic cancer is a highly aggressive malignancy with limited treatment options. CLK4 regulates alternative splicing, contributing to cancer progression. This study establishes a computational model to identify CLK4 inhibitors, leading to compound 150441 (IC50: 21.4 nm).
Chun‐Lin Yang, Yi‐Wen Wu, Huang‐Ju Tu, Yun‐Hsuan Yeh, Tony Eight Lin, Tzu‐Ying Sung, Mu‐Chun Li, Shih‐Chung Yen, Jui‐Hua Hsieh, Ming‐Chin Yu, Sen‐Yung Hsieh, Hsing‐Pang Hsieh, Shiow‐Lin Pan, Kai‐Cheng Hsu   +13 more
wiley   +1 more source

Licensing Considerations for OpenSim-Based Virtual Worlds

, 1970
Shenlei E. Winkler
openalex   +2 more sources

Performance evaluation of a firewall service based on virtualized IncludeOS unikernels. [PDF]

Sci Rep
Kurek T, Niemiec M, Lason A.
europepmc   +1 more source

Halofuginone Disrupted Collagen Deposition via mTOR‐eIF2α‐ATF4 Axis to Enhance Chemosensitivity in Ovarian Cancer

Advanced Science, EarlyView.
COL1A1, a major component of ECM, contributes to chemoresistance and poor prognosis in ovarian cancer. Halofuginone (HF) attenuates CAF‐secreted COL1A1 through mTOR‐eIF2α‐ATF4 axis. Notably, HF disrupts collagen deposition to form the looser ECM and facilitates CD8+ T cell infiltration, partially via M2‐M1 macrophage polarization to enhance ...
Wenxin Li, Yenan Wu, Yanan Zhang, Wenyan Gao, Xin Li, Haixia Luo, Mengmeng Lu, Zhihua Liu, Aiping Luo   +8 more
wiley   +1 more source

Estilos de aprendizaje aplicados a las aulas virtuales de lengua extranjera

, 1970
Wilmar Darío Macías-Romero
openalex   +2 more sources

Synchrotron Radiation‐Based Tomography of an Entire Mouse Brain with Sub‐Micron Voxels: Augmenting Interactive Brain Atlases with Terabyte Data

Advanced Science, EarlyView.
Extended‐field acquisition enables sub‐micron X‐ray imaging of a full mouse brain. The 3.3‐teravoxel volume is reconstructed, registered to a reference atlas, and stored in hierarchical format to augment currently available atlases and improve resolution in the third dimension by an order of magnitude.
Mattia Humbel, Christine Tanner, Marta Girona Alarcón, Georg Schulz, Timm Weitkamp, Mario Scheel, Vartan Kurtcuoglu, Bert Müller, Griffin Rodgers   +8 more
wiley   +1 more source