Results 21 to 30 of about 149 (148)

Enhancing patient engagement in cancer research: a focus on patient‐centric approaches to scientific discovery

Molecular Oncology, EarlyView.
Patient engagement involves actively including patients in healthcare decisions and research to ensure care and studies align with their needs. This approach improves outcomes, trust, and communication while fostering collaboration between patients and professionals.
Estela Cepeda, Marina Reguero, Vanesa Abón, Marta Puyol   +3 more
wiley   +1 more source

Identification of inhibitors of the Salmonella FraB deglycase, a drug target

FEBS Open Bio, EarlyView.
A high‐throughput screen was used to identify inhibitors of Salmonella FraB, a drug target. Characterization of top hits (identified after an additional counter screen) revealed that some triazolidines, thiadiazolidines, and triazolothiadiazoles are mixed‐type inhibitors of FraB.
Jamison D. Law, Yuan Gao, Sravya Kovvali, Pankajavalli Thirugnanasambantham, Vicki H. Wysocki, Brian M. M. Ahmer, Venkat Gopalan   +6 more
wiley   +1 more source

Virtual Symposium on Virtual Mind

Minds and Machines, 1992
When certain formal symbol systems (e.g., computer programs) are implemented as dynamic physical symbol systems (e.g., when they are run on a computer) their activity can be interpreted at higher levels (e.g., binary code can be interpreted as LISP, LISP code can be interpreted as English, and English can be interpreted as a meaninguful conversation ...
Hayes, P., Harnad, S., Perlis, D., Block, N.   +3 more
openaire   +3 more sources

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

Hydrophobicity causes anomalous migration of cystine/glutamate antiporter SLC7A11 in SDS‐PAGE with low acrylamide concentration

FEBS Open Bio, EarlyView.
SLC7A11 frequently migrates faster in SDS‐PAGE. The present study found that the high hydrophobicity of SLC7A11 causes its anomalous migration in SDS‐PAGE with a low concentration of acrylamide gel. Replacing isoleucine with asparagine reduced hydrophobicity and restored its normal migration at 55 kDa, revealing the role of hydrophobicity and gel ...
Nsengiyumva Emmanuel, Qian He, Yixin Kang, Dianbao Zhang, Min Gao, Minglin Wang, Kexin Fan, Jingwen Xiong, Shaobo Wu, Botao Fa, Zhengtao Xiao, Yingfang Niu, Jun Yao, Yilei Zhang   +13 more
wiley   +1 more source

Automatic skin flash optimization in breast and chestwall VMAT with static angle modulated ports: Effect of HU and flash margin size on plan quality and robustness

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Skin flash is typically added to breast and chestwall plans to ensure robust target coverage in the presence of respiratory motion, anatomic changes, and small setup uncertainties. Adding skin flash in volumetric modulated arc therapy (VMAT) plans is an iterative and manual process.
Emily Hubley, Brandon Koger, Taoran Li, Michael Salerno, Ryan M. Scheuermann, Lei Dong, Boon‐Keng Kevin Teo   +6 more
wiley   +1 more source

Improving organ dose sparing in left‐sided breast cancer with yaw‐limited volumetric modulated arc therapy: A dosimetric comparison to conventional and intensity modulated radiation therapy approaches

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Background To assess the dose‐sparing capabilities of a yaw‐limited volumetric modulated arc therapy (YL_VMAT) beam setup for adjacent organs at risk (OAR) in comparison with 3D‐conventional radiation therapy (3D‐CRT), intensity‐modulated radiation therapy (IMRT) and conventional VMAT for radiation therapy in left‐sided breast cancer patients.
Gerhard Pollul, Sascha Grossmann, Heiko Karle, Tilman Bostel, Heinz Schmidberger   +4 more
wiley   +1 more source

Commissioning of Halcyon enhanced leaf model in the Eclipse treatment planning system: Focus on simple slit fields and VMAT dose calculation

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose The dual‐layer multileaf collimator (MLC) in Halcyon adds complexities to the dose calculation process owing to the variability of dosimetric characteristics with leaf motion. Recently, an enhanced leaf model (ELM) was developed to refine the MLC model in the Eclipse treatment planning system. This study investigates the performance of
Ryohei Miyasaka, Mari Shirai, Mitsunobu Igari, Yume Kojima, Yuki Kozawa, Toru Kawachi, Ryusuke Hara   +6 more
wiley   +1 more source

Virtual Action Research for Virtual Organisations? [PDF]

Systemic Practice and Action Research, 2016
Business organisations have always existed in a constantly changing environment. To survive it is necessary for them to adapt and adjust to the changes. When analysing complex entities, such as organisations, researchers have frequently adopted the methods of action research.
Stowell, Frank, Cooray, Shavindrie
openaire   +3 more sources

Facilitating 1.5T MR‐Linac adoption: Workflow strategies and practical tips

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Background MR‐guided radiotherapy (MRgRT) offers new opportunities but also introduces workflow complexities requiring dedicated optimization. Implementing magnetic resonance linear accelerator (MR‐Linac) technology comes with challenges such as prolonged treatment times and workflow integration issues.
Madeline Michel, Zelda Paquier, Christelle Bouchart, Akos Gulyban, Nicolas Jullian, Dirk Van Gestel, Sara Poeta, Nick Reynaert, Philippe Martinive, Robbe Van Den Begin   +9 more
wiley   +1 more source