Results 171 to 180 of about 5,704,045 (246)

Organic Electrochemical Transistors for Neuromorphic Bioelectronics: Materials and Manufacturing Technologies

open access: yesAdvanced Science, EarlyView.
Organic electrochemical transistors bridge biological ionic signaling and neuromorphic computation through volumetric electrochemical gating. This review connects Organic mixed ionic–electronic conductor materials, device architectures, and manufacturing technologies to show how geometry, ion transport, and fabrication strategies program plasticity ...
Hyunjin Lee   +5 more
wiley   +1 more source

FTSJ3‐Mediated 2′‐O‐Methylation of HSPA5 mRNA Stabilizes BOP1 via SUMOylation to Drive DRP1‐Dependent Mitochondrial Fission and Fatty Acid Oxidation in Lung Squamous Cell Carcinoma

open access: yesAdvanced Science, EarlyView.
The RNA methyltransferase FTSJ3 drives lung squamous cell carcinoma progression by catalyzing 2′‐O‐methylation of HSPA5 mRNA, which stabilizes BOP1 through SUMOylation and activates DRP1/SREBP1‐mediated mitochondrial fission and fatty acid oxidation. Targeting this axis with liposomal siRNA potently suppresses tumor growth and metastasis ABSTRACT Lung ...
Qin Hu   +4 more
wiley   +1 more source

Integrating Kinetics into Synthetic Studies via Adaptable Concentration‐Dependent Yield Analysis

open access: yesAdvanced Science, EarlyView.
A method to derive kinetic parameters from synthetic studies was developed and named concentration‐dependent yield analysis (CYAN). Using numerical Euler integration for kinetic regression, CYAN was proven adaptable to chemical and operational considerations and revealed unexpected template effects of a transition metal that mediated competitive ...
Xinyi Xiao   +4 more
wiley   +1 more source

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

open access: yesAdvanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang   +12 more
wiley   +1 more source

Synergistic Regulation of Deep‐Cycling‐Induced Zn Pulverization and Resting Galvanic Corrosion in Practical Lean Zinc Anodes

open access: yesAdvanced Science, EarlyView.
Benzotriazole (BTA) regulates Zn reduction kinetics and suppresses galvanic corrosion, simultaneously mitigating Zn pulverization during cycling and self‐corrosion during storage, thereby enabling lean Zn anodes with enhanced cycling stability and extended calendar life.
Jing Xu   +7 more
wiley   +1 more source

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