Results 31 to 40 of about 5,704,045 (246)

THEORY OF BIOHAPPINESS AND GENETIC VIRTUE OF MARK WALKER

open access: yesRussian Studies in Culture and Society, 2022
Mark Walker, one of the ideologists of modern transhumanism, developed a number of neuroethics provisions for the implementation of the “human enhancement” project.
Julia V. Khvastunova
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

open access: yesMolecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee   +3 more
wiley   +1 more source

Virtue Ethics, Confucian Tradition and the General Predicament of Modern Society

open access: yesAsian Studies
This paper discusses the nature of Confucian ethics and its tense relations with modernity through analysing the arguments contained in Chen Lai’s 陈来 Confucian Theory of Virtue.
Wenming TANG
doaj   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

open access: yesMolecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David   +12 more
wiley   +1 more source

Virtue Jurisprudence: A Virtue-Centered Theory of Judging [PDF]

open access: yes, 2003
Virtue jurisprudence is a normative and explanatory theory of law that utilizes the resources of virtue ethics to answer the central questions of legal theory. The main focus of the essay is the development of a virtue-centered theory of judging. The
Solum, Lawrence B.
core   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

open access: yesFEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao   +23 more
wiley   +1 more source

Ethical Foreground and Background in Adult Educator Work

open access: yesNew Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Adult educators work in a complex ethical environment. The very act of contributing to the learning of another is fraught with moral overtones. In this paper we consider the ethical dimensions of adult educator practice by distinguishing the ethical features of the context or ‘background’ of practice from the ethical capabilities and decision ...
Steven Hodge, Sonal Nakar
wiley   +1 more source

Aristotelský argument z ergon a současné teorie ctností

open access: yesFilosofický časopis, 2023
Contemporary neo-Aristotelian virtue ethics engage in great detail with the concept of human nature. This is also the case with Philippa Foot and Rosalind Hursthouse, who, in their argumentation, use the so-called ergon argument that can be unambiguously
Hloch, Roman
doaj   +1 more source

Manifestations of Virtue [PDF]

open access: yes, 2020
Few philosophers endorse a virtue theory of praiseworthiness. The widespread aversion to any virtue theory of moral worth rests chiefly on a skeptical argument that emphasizes the fact that praiseworthy acts can be performed by people who lack the ...
Arden Ali, Ali, Arden
core   +3 more sources

A Rejection of Ethical Error Theory based on Evolutionary Explanation of Ethics [PDF]

open access: yesحکمت و فلسفه, 2011
Error theory in modern ethics is known by the name of John Mackie. According to him, all moral claims are false. Since 1970s, there has been a great deal of research to explain human ethics by biological evolutionary theory.
hasan miandari
doaj   +1 more source

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