Results 211 to 220 of about 187,700 (310)

PRMT9 Aggravated Dopaminergic Neurodegeneration in Parkinson's Disease Model by Facilitating the Degradation of DUSP26 and Inducing Mitochondrial Dysfunction

Advanced Science, EarlyView.
In the pathological state of PD induced by MPP+, the upregulated PRMT9 in dopaminergic neurons translocates into mitochondrion and interacts with DUSP26 and catalyzes its arginine methylation, leading to the ubiquitin‐proteasomal degradation of DUSP26 mediated by Trim32.
Tengfei Liu, Xiaomeng Song, Xin Guo, Rui Xiao, Ru Sun, Qiuran Ji, Lu Yu, Yiquan Li, Qingyi Fu, Qidi Xue, Lingjun Kong, Lin Chen, Chengjiang Gao, Huiqing Liu   +13 more
wiley   +1 more source

Development and immunogenicity of adenoviral Fc-fused FMDV virus-like particle vaccine in swine. [PDF]

Vet Q
Park JY, Lee HM, Kang KJ, Jung MK, Mun JY, Kim MJ, Pyun JC, Hwang SY, Park JH, Shin HJ.   +9 more
europepmc   +1 more source

Surfaceome Reprogramming of Stemsomes Promotes Lung Cancer Targeting via Potentiated Receptor–Ligand Interactions

Advanced Science, EarlyView.
This study presents a surfaceome‐reprogramming strategy for mutation‐independent lung cancer therapy by repurposing dexamethasone to prime mesenchymal stem cell‐derived nanovesicles. The engineered vesicles leverage multi‐valent interactions mediated by upregulated adhesion proteins, EPHA2, and NOTCH3.
Geunhye Kim, In Ah Kwon, Bo Seop Jeong, Hyo Seon Kim, Joo‐Hwan Park, Sung Jean Park, Sang‐Rae Lee, Youngki Lee, Dongwoo Khang   +8 more
wiley   +1 more source

Astragalus Polysaccharide Nanoemulsion: A Promising Adjuvant for Foot-And-Mouth Disease Virus-Like Particle Vaccines. [PDF]

Transbound Emerg Dis
Shi X, Teng Z, Yang K, Song H, Zhang Y, Tan S, Dong H, Sun S, Ding Y, Guo H.   +9 more
europepmc   +1 more source

ZNF33B Promotes Japanese Encephalitis Virus Infection by Regulating the Stability of M6A‐Modified Trim25 to Control the Autophagy Process

Advanced Science, EarlyView.
Upon JEV infection, ZNF33B recruits METTL14 to stabilize the METTL3‐METTL14 m6A methyltransferase complex, leading to increased m6A modification of host transcripts, including Trim25 mRNA. ZNF33B selectively binds m6A‐modified sites on Trim25 mRNA and accelerates its decay, resulting in reduced TRIM25 protein abundance.
Jian Du, Chunwei Li, Jiyuan Luo, Huizhi Zhang, Jinyan Zhang, Suya Wang, Huanchun Chen, Hongli Xu, Xiangmin Li, Ping Qian   +9 more
wiley   +1 more source

A chikungunya virus-like particle vaccine reduces chikungunya disease in cynomolgus macaques and protection is mediated by antibody transferred from vaccinated humans. [PDF]

NPJ Vaccines
Coffey LL, Olstad KJ, Reader JR, Ardeshir A, Weiss CM, Watanabe JK, Usachenko JL, Yee J, Singapuri A, Ma ZM, Mackiewicz A, Sammak R, Stuart J, Immareddy R, Anantha R, Warfield KL, Manayani D, Alexander J, Smith J, Vang L, Cirimotich CM, O'Connor C, Guenther B, Ho N, Morello CS, Mendy J, Richardson JS, Van Rompay KKA.   +27 more
europepmc   +1 more source

Solar‐Driven Bifunctional Adsorption‐Storage Films for Ultra‐Fast Dehumidification and Freshwater Supply in Low‐carbon Buildings

Advanced Science, EarlyView.
Bifunctional adsorption‐storage films enable autonomous indoor humidity regulation and freshwater harvesting, rapidly decreasing relative humidity from 90.7% to 21.6% within one hour while producing 1.1 kg·m−2·day−1 of water, offering a passive route towards energy‐efficient humidity control and sustainable indoor environments. ABSTRACT Indoor humidity
Yuechao Chao, Junwei Liu, Zhihua Zhou, Yahui Du, Hailu Wei, Haibin Yang, Xueqing Yang, Cheng Wang, Zhenzhong Zeng, Hongzhi Cui, Jinyue Yan   +10 more
wiley   +1 more source

Impact of Host Cell DNA and Chromatin on Virus-like Particle Analysis by Light Scattering in Asymmetrical Flow Field-flow Fractionation. [PDF]

J Sep Sci
Bacher J, Jakob LA, Mesurado T, Lali N, Zollner A, Jungbauer A, Pereira Aguilar P.   +6 more
europepmc   +1 more source

Radiation‐Induced Tumor‐Intrinsic LTβR N‐Glycosylation Suppresses Pyroptosis Through TRIM28‐Mediated PCBP2 SUMOylation to Promote Gastric Cancer Radioresistance

Advanced Science, EarlyView.
Radiotherapy triggers LTβR N‐glycosylation, enhancing its overall protein stability and nuclear retention. This accumulation drives TRIM28‐mediated PCBP2 SUMOylation, suppressing pyroptosis and conferring gastric cancer radioresistance. Therapeutically, a targeted nanoplatform (cRGD‐Lipo@EMD) effectively disrupts this regulatory axis, offering a highly
Weijie Zang, Yunlong Ji, Chunwang Zhou, Xiwen Li, Zhuang Lu, Guangze Zhang, Yu Chen, Wanjiang Xue, Yilin Hu   +8 more
wiley   +1 more source

Safety and Efficacy of Plant-Produced Trivalent Virus-Like Particle Vaccine Candidate Against Bluetongue Disease. [PDF]

Plant Biotechnol J
Mlingo TAM, O'Kennedy MM, Matsiela M, Nkomo N, Coetzee P, Rametse T, Mutowembwa P, Heath L, Mokoena N.   +8 more
europepmc   +1 more source