Results 171 to 180 of about 34,040 (263)

YAP1‐Driven Pathogenic Fibro‐Adipogenic Progenitors Secrete IL‐6 and FGF21 to Mediate Muscle‐Bone Crosstalk and Promote Bone Loss

Advanced Science, EarlyView.
Fibro‐adipogenic progenitors (FAPs) in atrophic muscle undergo YAP1‐driven pathogenic activation, secreting IL‐6 and FGF21 as bone‐catabolic myokines that mediate muscle‐bone crosstalk and promote bone loss. Genetic or pharmacological targeting of this YAP1‐FAP‐myokine axis rescues skeletal deterioration, identifying FAP‐derived myokines as therapeutic
Xiaoyu Cai, Tao Xu, Rui Ma, Weikun Meng, Shutao Gao, Yakefu Abulizi, Alafate Kahaer, Chuanhui Xun, Maierdan Maimaiti, Rui Cao, Weidong Liang, Polati Maimaiti, Qiang Deng, Jun Sheng, Ting Wang, Mingchong Liu, Weibin Sheng   +16 more
wiley   +1 more source

New Tools Against Old Enemies: Respiratory Syncytial Virus (RSV) in Older Adults. A Narrative Review. [PDF]

Farm Comunitarios
Luque Del Moral R, Alberto Armas D.
europepmc   +1 more source

Intratumoral Hypoxia Triggers Mitochondrial BHLHE40 ROS Sensing Pathway to Promote Radioresistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Hypoxia triggers a dual mechanism for BHLHE40 upregulation: reactive oxygen species (ROS)‐dependent post‐translational modification and hypoxia‐inducible factor (HIF)‐dependent transcriptional activation. Under hypoxic conditions, mitochondrial BHLHE40 accumulates and senses ROS via cysteine thiol oxidation and disulfide‐linked homodimer formation ...
Jia Liu, Ziliang Nie, Xi Chen, Guangyu Ji, Yajing Zhang, Zhiqun Zhao, Yuhong Zhang, Xinlong Du, Zhenzhen Zhou, Jiayi Li, Yaozong Yang, Fengqi Sun, Zhibo Yan, Haiquan Lu   +13 more
wiley   +1 more source

Airway organoids reveal patterns of influenza A tropism and adaptation in wildlife species. [PDF]

Emerg Microbes Infect
Tarrés-Freixas F, Ceada G, Català-Moll F, Casadellà M, Tolosa-Alarcón S, Franco-Trepat E, Boreika R, Almagro-Delgado V, Carmona N, Estruch J, Fernández-Bellon H, Fuentes-Moyano L, Molina-López R, Navarro N, Parera M, Pérez-Simó M, Repullés J, Roca N, Torné O, Velarde R, Valencia A, Paredes R, Izquierdo-Useros N, Romero-Durana M, Kochanowski K, Vergara-Alert J.   +25 more
europepmc   +1 more source

UFL1‐Mediated UFMylation of ENO1 Restrains Aerobic Glycolysis and Colorectal Cancer Progression

Advanced Science, EarlyView.
UFMylation restrains aerobic glycolysis and colorectal cancer progression by modifying the glycolytic enzyme ENO1. Pharmacological enhancement of the UFL1–ENO1 interaction by the FDA‐approved antibiotic torezolid promotes ENO1 UFMylation, suppresses tumor metabolism, and sensitizes colorectal cancer to chemotherapy, revealing an actionable metabolic ...
Xiuqing Ma, Rui Wan, Yueyuan Zhong, Ziyang Cui, Xuan Zhang, Xiaoqiang He, Rong Wang, Lei Huang, Wan‐Yang Sun, Rong‐Rong He, Yang Zhou, Jianshuang Li, Li Shen, Shao‐Hua Wang, Tongzheng Liu   +14 more
wiley   +1 more source

COVID-19 Vaccine Effectiveness Among Older Adults.

JAMA Netw Open
Laniece Delaunay C, Mateo-Urdiales A, Pérez-Gimeno G, O'Reilly K, Uras M, Erdwiens A, Mlinaric I, Túri G, Martínez-Baz I, Meijer A, Rodrigues AP, Lazar M, Latorre-Margalef N, Lucaccioni H, Verdasca N, Bella A, Rafael de la Cruz Lopez MA, Kelly E, Enouf V, Tolksdorf K, Puzelli S, Ibáñez Pérez AC, Fitzgerald M, Masse S, Oh DY, Kaczmarek M, Bacci S, Kissling E, VEBIS Primary Care Vaccine Effectiveness Group.   +28 more
europepmc   +1 more source

[Environmental medicine and AI, migration, and emerging and reemerging diseases in Mexico]. [PDF]

Rev Med Inst Mex Seguro Soc
Rivera-Silva G, Moreno-Treviño MG, Garza-Martínez R.   +2 more
europepmc   +1 more source

Tumor‐Derived Exosomal circAP2B1 Induces M2 Macrophage Polarization by Enhancing Mitochondrial Homeostasis to Promote Esophageal Squamous Cell Carcinoma Progression

Advanced Science, EarlyView.
ESCC‐derived exosomal circAP2B1 promotes tumor progression by reprogramming mitochondrial metabolism via the ESRRA/KPNA1/MFN2 axis to induce M2 polarization of macrophages. ABSTRACT Esophageal squamous cell carcinoma (ESCC) remodels the immunosuppressive tumor microenvironment via exosome‐mediated intercellular communication.
Yiru Wang, Gang Feng, Youyu Wang, Ruihao Liang, Haixia Pan, Kai Lei   +5 more
wiley   +1 more source

Influenza vaccine effectiveness from nine studies during drifted A(H3N2) subclade K predominance, Europe, September 2025 to January 2026. [PDF]

Euro Surveill
Lucaccioni H, Marques DF, Kirsebom F, Emborg HD, Hamilton M, Whitaker H, Bolt Botnen A, Bucholc M, Pozo F, Andrews N, Trebbien R, Hameed SS, Lauenborg Møller K, O'Doherty MG, Lopez-Bernal J, Morrison K, Cottrell S, Wilton S, Rose AM, Kissling E, European IVE group.   +20 more
europepmc   +1 more source

Systematic Multi‐Level Analyses Decode the Arthritis‐Neurodegeneration Axis With In Vivo Validation

Advanced Science, EarlyView.
Arthritis and neurodegeneration are usually studied as separate disorders, but this study connects them through population evidence, genetic inference, transcriptomic mapping, and mouse models. It highlights RNF40 as a context‐dependent joint‐brain candidate, induced in inflammatory joints yet functionally linked to dopamine‐neuron vulnerability ...
Jinwen Wang, Wenhui Xie, Lei Yang, Zhengrong Wang, Yi Huang, Peng Huang, Yuan Liu, Jun Hu   +7 more
wiley   +1 more source