Results 171 to 180 of about 124,032 (305)

Design of Safe and Efficient Adenine Base Editors via Protein Language Model Screening for Osteoarthritis Treatment

Advanced Science, EarlyView.
ABSTRACT Base editors enable precise genome modification and have emerged as a promising therapeutic approach for correcting diseases caused by single‐nucleotide variants. While the current efficient version of adenine base editors (ABEs), such as ABE8e, exhibits exceptional efficiency for A‐to‐G conversions, their clinical translation is hindered by ...
Jiawei Yao, Dalin Chen, Ziyi Zhang, Jingxuan Ren, Chengcheng Zhao, Shengfang Wang, Mengyu Shang, Dawei Jiang, Yinuo Li, Su'an Tang, Kai Li, Xiaohui Zhang, Xiaogang Wang   +12 more
wiley   +1 more source

Respiratory Viral Co-Infections in SARS-CoV-2 Positive Patients in Burkina Faso: A Cross-Sectional Study. [PDF]

Health Sci Rep
Kaboré BWO, Gouba N, Ilboudo AK, Cissé A, Lingani M, Sawadogo C, Ouédraogo EW, Ouoba JB, Savadogo M, Tarnagda Z.   +9 more
europepmc   +1 more source

Caracterización de anticuerpos monoclonales dirigidos contra la proteína de exportación nuclear (NEP) del virus de Influenza A H1N1

, 2020
"Los virus de la influenza son responsables de causar epidemias anuales, por lo que se deben de buscar tratamientos dirigidos a puntos clave de su replicación y de proteínas altamente conservadas entre diferentes subtipos. La proteína de exporte nuclear (NEP) cumple con estas características con una alta identidad del 93.4% entre diferentes aislados ...
openaire   +2 more sources

Tumor‐Derived Alpha‐1 Antitrypsin Promotes Liver Metastasis of Colorectal Cancer Through the Neutrophil Extracellular Traps–CCDC25 Pathway

Advanced Science, EarlyView.
ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei, Chunning Li, Lei Zhan, Xiaoyan Li, Yan Hui, Yue Jin, Jing Zhang, Lu Yang, Xin Sun, Xiaoxi Li, Qian Dong, Jingdong Zhang   +11 more
wiley   +1 more source

Investigation and impact of mammalian adaptation markers on H5N8 high pathogenicity avian influenza polymerase activity. [PDF]

Npj Viruses
Fusade-Boyer M, Kocher A, Bessière P, Figueroa T, Foret-Lucas C, Vergne T, Chevalier C, Ducatez MF, Volmer R.   +8 more
europepmc   +1 more source

A Microbial Lipid‐ATP Synthase Axis Fuels NK Cell Antitumor Activity

Advanced Science, EarlyView.
This study focuses on the mechanism by which gut microbiota‐derived outer membrane vesicles (OMVs) regulate NK cell antitumor activity. B. intestinalis is identified to decrease extra‐intestinal tumor growth via its OMVs enriched in sphingosine (SP).
Kaiyuan Yu, Xinyu Sun, Wanxia Ma, Jianming Yang, Xuan Sun, Lisong Zhang, Yumeng Liu, Tianshu Ren, Qi Wang, Jingyu Wang, Xiao Li, Xianping Peng, Liu Yang, Junqiang Lv, Zhi Yao, Zhi‐Song Zhang, Quan Wang   +16 more
wiley   +1 more source

Senolytic Treatment Reduces Acute and Chronic Lung Inflammation in an Aged Mouse Model of Influenza. [PDF]

Aging Cell
Delval L, Creskey M, Valentin C, Bordas C, Raviola S, Lipskaia L, Heumel S, Deruyter L, Sencio V, Wolowczuk I, Bernard D, Adnot S, Gosset P, Zhang X, Trottein F.   +14 more
europepmc   +1 more source

A NeuroD1 AAV‐Based Gene Therapy for Functional Brain Repair in Alzheimer's Disease‐Like Non‐Human Primate Model

Advanced Science, EarlyView.
This study tests NeuroD1 AAV‐based gene therapy in a non‐human primate Alzheimer's disease model. The therapy prevents neuronal damage, inhibits hippocampal atrophy, and reduces neuroinflammation. It also repairs vascular and blood‐brain barrier damage, restores cerebrospinal fluid biomarkers, enhances hippocampal glucose metabolism, and improves ...
Zhouquan Jiang, Yongpeng Qin, Bin Luo, Fan Bai, Jiangyue Liu, Long Ma, Shu He, Rongjie Chen, Yuchen Wang, Shanggong Liu, Ying Sun, Yi Chen, Shuo Zhang, Jiaqi Liang, Feng Liao, Huiyi Wei, Junjie Wei, Lu Wang, Hao Xu, Zheng Wu, Gong Chen, Wenliang Lei   +21 more
wiley   +1 more source

MVP Inhibits Influenza A Virus‐Induced Ferroptosis by Targeting IRF1 and Increasing FSP1 Activity

Advanced Science, EarlyView.
During IAV infection, MVP inhibits IRF1 polyubiquitination, thereby relieving IRF1‐mediated transcriptional inhibition of FSP1. Consequently, this leads to an upregulation of FSP1 expression, thereby reinforcing the inhibition of ferroptosis. In addition, the MVP can promote myristoylation and ubiquitination of FSP1, enabling its membrane localization ...
Yingbo Chen, Paili Lin, Yongfang Xia, Zhiqiang Liu, Zilu Cheng, Qingmei Zhu, Shiqi Wan, Xiaoyu Chen, Haiyan Bao, Renbo Qiao, Gechang Zhong, Ying Zhu, Shi Liu   +12 more
wiley   +1 more source

Airway organoids reveal patterns of influenza A tropism and adaptation in wildlife species. [PDF]

Emerg Microbes Infect
Tarrés-Freixas F, Ceada G, Català-Moll F, Casadellà M, Tolosa-Alarcón S, Franco-Trepat E, Boreika R, Almagro-Delgado V, Carmona N, Estruch J, Fernández-Bellon H, Fuentes-Moyano L, Molina-López R, Navarro N, Parera M, Pérez-Simó M, Repullés J, Roca N, Torné O, Velarde R, Valencia A, Paredes R, Izquierdo-Useros N, Romero-Durana M, Kochanowski K, Vergara-Alert J.   +25 more
europepmc   +1 more source