Results 201 to 210 of about 43,232 (314)

Caractérisation de facteurs impliqués dans l'adaptation des virus influenza à leurs hôtes : exemple de la protéine NS1

, 2010
Sébastien Soubiès
openalex   +1 more source

Genetic and Serological Analysis of H7N3 Avian Influenza Viruses in Mexico for Pandemic Risk Assessment. [PDF]

Viruses
Ayora-Talavera G, López-Martínez I, Barrera-Badillo G, Aparicio-Antonio R, Aréchiga-Ceballos N, Aguirre-Barbosa A, Wong-Chew RM, Canul-Canul D, Solís-Hernández M.   +8 more
europepmc   +1 more source

Targeting DNA‐LNPs to Endothelial Cells Improves Expression Magnitude, Duration, and Specificity

Advanced Science, EarlyView.
Attaching antibodies against endothelial cell surface proteins redirects the delivery and expression of DNA‐lipid nanoparticles to organs of interest. Our targeted nanoparticles enable organ‐selective DNA expression in the endothelium of the lungs, brain, or spleen, providing a therapeutic platform for dozens of endothelial‐centric diseases.
Nicolas Marzolini, Taylor V. Brysgel, Ryan J. Rahman, Eno‐Obong Essien, Saw Y. Nwe, Jichuan Wu, Aparajeeta Majumder, Manthan N. Patel, Sachchidanand Tiwari, Carolann L. Espy, Fengyi Dong, Sabrina A. Santos‐De León, Anit Shah, Vladimir V. Shuvaev, Elizabeth D. Hood, Liam S. Chase, Drew Weissman, Jeremy B. Katzen, David B. Frank, Mariko L. Bennett, Oscar A. Marcos‐Contreras, Jacob W. Myerson, Vladimir R. Muzykantov, Sahily Reyes‐Esteves, Jacob S. Brenner   +24 more
wiley   +1 more source

Inhibition of Calcium‐Dependent Lipid Droplets Relocation of ACSL4‐PKCβ‐ALOX15 Complex Alleviates Ferroptosis and Acute Pancreatitis

Advanced Science, EarlyView.
This study identifies L‐type calcium channel blockers as novel ferroptosis inhibitors. It reveals that PKCβ, activated in calcium dependent manner, phosphorylates and activates ACSL4 and ALOX15, relocating them to lipid droplets to promote lethal lipid peroxidation and ferroptosis.
Guoyuan Hou, Jing Luan, Xiaoyong Xu, Jianhua Qin, Shuang Ma, Jiyuan He, Na Sun, Wei Zhang, Minghui Gao   +8 more
wiley   +1 more source

Type I IFN autoantibodies underlie chikungunya live-attenuated vaccine encephalitis. [PDF]

Proc Natl Acad Sci U S A
Gervais A, Bastard P, Zhang Q, Jaffar-Bandjee MC, Bizien L, Dahmane L, Moiton MP, Jabot J, Cally R, Maillard A, Frumence E, de Lamballerie X, Yazdanpanah Y, Rosain J, Cobat A, Abel L, Puel A, Ferdynus C, Mosnier É, Gérardin P, Zhang SY, Casanova JL.   +21 more
europepmc   +1 more source

The Regulatory Role of Iron Transporter SLC39A13 in Liver Fibrosis

Advanced Science, EarlyView.
SLC39A13/ZIP13, a newly discovered intracellular iron transporter, delivers iron to the ER/Golgi to catalyze procollagen hydroxylation during collagen maturation. Here, we systematically characterize the cell type‐specific functions of ZIP13 across distinct hepatic cell populations, and identify hepatic stellate cell‐specific ZIP13 as a promising and ...
Shanshan Guo, Yalin Wang, Binyu Lu, Yu Zhang, David M. Frazer, Bing Zhou   +5 more
wiley   +1 more source

Contribution de la protéine PB1-F2 des virus influenza A dans l’adaptation d’une souche virale à son hôte

, 2021
Joëlle Mettier
openalex   +1 more source

[Brief history of laboratory-based epidemiological surveillance in the Mexican Institute for Social Security]. [PDF]

Rev Med Inst Mex Seguro Soc
Santacruz-Tinoco CE, Alvarado-Yaah JE, Anguiano-Hernández YM, Martínez-Miguel B, Cabrera-Gaytán DA, Chávez-Navarro L.   +5 more
europepmc   +1 more source

Genome‐Wide Codon Reprogramming Enables a Multifactorially Attenuated Influenza Vaccine with Broad Cross‐Protection

Advanced Science, EarlyView.
Genome‐wide codon reprogramming of influenza A virus introduces 1956 synonymous mutations across five segments and elevates CpG content, causing defective NA packaging, loss of NS1 accumulation, and enhanced ZAP‐mediated antiviral responses without affecting RNA or protein synthesis. These mechanisms result in profound attenuation and potent homologous
Yang Wang, Tianxin Ma, Yujiao He, Qinming Li, Kailin Mai, Minying Mo, Chenyang Cao, Jiahui Li, Pei Feng, Jiaojiao Peng, Jing Sun, Weiqi Pan, Zifeng Yang, Ling Chen   +13 more
wiley   +1 more source

Etude de la faculté des protéines MX porcines à conférer une résistance contre le virus influenza A et contribution à l'identification du mécanisme impliqué

, 2013
Melanie D. Palm
openalex   +1 more source