Results 201 to 210 of about 124,032 (305)

Broad-spectrum antiviral activity of the synthetic rocaglate zotatifin against Mayaro virus and other viruses. [PDF]

Front Cell Infect Microbiol
Valdés-Torres P, Campos D, Galán-Jurado PE, Zegarra D, Tuñon-Lorenzo I, González-Castillo F, Blanquer M, Mewa JC, Rivas C, González-Santamaría J.   +9 more
europepmc   +1 more source

Metabolic Imbalance Triggers Adaptive Remodeling to Accelerate Diploidization in Murine Haploid Embryonic Stem Cells

Advanced Science, EarlyView.
In this article, Shuai and colleagues demonstrate that metabolic remodeling drives self‐diploidization in murine haploid ESCs (haESCs). Mitochondrial dysfunction and imbalanced pyruvate metabolism underlie this process. Genome‐wide screening using haESCs identifies key mitochondrial quality‐control related genes, enabling a metabolism‐based medium that
Yi Fu, Wenhao Zhang, Yifan Zhang, Yu He, Yi Du, Yiding Zhao, Chunmeng Yao, Shengyi Sun, Xiaoyan Sheng, Qian Gao, Chao Tong, Ling Shuai   +11 more
wiley   +1 more source

Early nasal and lung transcriptomic profiles reveal pathways associated with divergent clinical outcomes following H7N1 high pathogenicity avian influenza virus infection. [PDF]

Poult Sci
Valdez-May MJ, Nofrarías M, Pina-Pedrero S, Dabad M, Valle R, Pérez M, Esteve-Codina A, Argilaguet J, Majó N, Bertran K.   +9 more
europepmc   +1 more source

ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid‐β Pathology

Advanced Science, EarlyView.
This study identifies that ALKBH3‐driven m1A demethylation orchestrates Alzheimer's disease progression by disrupting mitochondrial and synaptic homeostasis. This epitranscriptomic mechanism suppresses PINK1‐mediated mitophagy via m1A erasure, leading to mitochondrial dysfunction, oxidative stress, elevated Aβ production, and impaired microglial ...
Yueyang Li, Sifei Yu, Kaidong Lu, Yujie Zhang, Mingjie Dong, Yan Peng, Liang Xue, Waleed Alam, Yuxuan Shui, Yi Zhou, Wuyunhan Ma, Meng Bao, Peiming Li, Peiyi Luo, Tiezhan Lu, Jiajia Li, Kang Zhang, Yuying Wang, Shuchen Yang, Nuoya Yin, Francesco Faiola, Zilong Gao, Jingfeng Zhou, Fei Zhao, Yali He, Magdalena J. Koziol   +25 more
wiley   +1 more source

Highly Pathogenic Avian Influenza A(H5N1) Clade 2.3.4.4b Virus Infection in Poultry Farm Workers, Washington, USA, 2024. [PDF]

Emerg Infect Dis
Hatta Y, De La Cruz JA, Murray T, Hiatt B, Jang Y, Frederick JC, Lacek KA, DaSilva JC, Cui D, Carney P, Liddell J, Radford KW, Burnett N, Schatzman S, Trinh P, Unutzer A, Pusch EA, Johnson M, Nguyen HT, Rambo-Martin BL, Gubareva L, Stevens J, Davis CT, Kirby MK, Black A, Di H.   +25 more
europepmc   +1 more source

Reinforcing Calcium Overload via Inflammation‐Mediated Targeting to Amplify Pyroptosis and Antitumor Immunity

Advanced Science, EarlyView.
A neutrophil‐membrane‐camouflaged nanoplatform (RC@NMVs) exploits tumor inflammation to target and accumulate in tumors. Intracellular Ca2+ overload is triggered via lysosomal CaP dissolution and Ru red‐mediated Ca2+ channel blockade, synergistically inducing gasdermin‐mediated pyroptosis.
Yingying Liu, Yang Liu, Qin Fan, Jinqiao Zhang, Kexin Wen, Boyu Yuan, Xianzhou Cai, Ziliang Dong, Lianhui Wang   +8 more
wiley   +1 more source

Mass‐Produced and High‐Performance Nanowell Biosensor Fabricated via Semiconductor Manufacturing for Rapid and Accurate COVID‐19 Diagnosis in the Clinical Field

Advanced Science, EarlyView.
A semiconductor‐fabricated nanowell biosensor enables rapid, scalable, and highly reproducible detection of SARS‐CoV‐2 antigens from nasal swabs within ∼10 minutes. Clinical validation in 249 retrospective and 243 prospective patient samples demonstrates high sensitivity and specificity, minimal cross‐reactivity, and robust batch‐to‐batch ...
Yoo Min Park, Zahra Rezaei, Nam Ho Bae, Donggee Rho, Da‐Seul Kim, EunYoung Go, YoungTae Seo, Seok Jae Lee, Won Chan Seo, Luke P. Lee, HeaYeon Lee, Su Ryon Shin   +11 more
wiley   +1 more source

Deciphering the etiology of the 2024 outbreak of undiagnosed febrile illness in Panzi, Democratic Republic of the Congo. [PDF]

Nat Med
Wawina-Bokalanga T, Makangara-Cigolo JC, Ola-Mpumbe R, Lokilo E, Mwakisenda-Tshakotsho F, Delphine M, Kahindo I, Tshonaka-Nkololo A, Vakaniaki EH, Loman N, Houben S, Lumembe-Numbi R, Kinganda-Lusamaki E, Ponga-Museme A, Mukota-Nungu Y, Kumar A, Meris M, Wilkinson S, Colquhoun R, Kenye KM, Akil-Bandali P, Amuri-Aziza A, Martinez GS, Kelvin DJ, Dijkman R, Hensley LE, Kasita C, Kafua-Wemba F, Mwamba D, Subissi L, Hoff NA, Peeters M, Rimoin AW, Mokili JL, Lunguya-Metila O, Nkwembe E, Rambaut A, Liesenborghs L, Low N, Kindrachuk J, Vercauteren K, Edwards R, Kelly JN, Mbala-Kingebeni P, Ahuka-Mundeke S, Mumba D, Muyembe-Tamfum JJ.   +46 more
europepmc   +1 more source

Gasdermin D‐Mediated Release of IL‐33 Results in Fetal Brain Developmental Abnormalities During Maternal Colitis

Advanced Science, EarlyView.
Under colitis, Gsdmd mediates the release of IL‐33 from the epithelium of pregnant mice. IL‐33 can cross the placenta and enhance the proliferative capacity of neural stem cells, ultimately resulting in behavioral deficits in the offspring. Excessive pyroptosis in the colonic epithelium also triggers the translocation of LPS, which in turn increases ...
Huiyang Jia, Shukui Zhang, Kai Ma, Jie Zhou, Jianwei Jiao   +4 more
wiley   +1 more source

Epidemiological patterns of influenza viruses among severe acute respiratory infection patients in Burkina Faso, 2016-2019: a surveillance study. [PDF]

Pan Afr Med J
Lingani M, Cissé A, Ilboudo AK, Bicaba B, Yaméogo I, Tarnagada Z.   +5 more
europepmc   +1 more source