Results 191 to 200 of about 4,863,377 (394)

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Genetic Diversity of Infectious Bronchitis Virus Genotype II in Poland

Pathogens
The epidemiological situation in Poland for IBV GII (formerly known as D1466) has seemed stable over the years, but an increase in such infections has been recently reported. In this study, genetic characterization of the representatives of this genotype
Anna Pikuła, Anna Lisowska, Justyna Opolska, Katarzyna Domańska-Blicharz   +3 more
doaj   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Exploring Avian Influenza Viruses in Yakutia—The Largest Breeding Habitat of Wild Migratory Birds in Northeastern Siberia

Viruses
Yakutia, the largest breeding ground for wild migratory birds in Northeastern Siberia, plays a big role in the global ecology of avian influenza viruses (AIVs).
Nikita Kasianov, Kirill Sharshov, Anastasiya Derko, Ivan Sobolev, Nikita Dubovitskiy, Arina Loginova, Evgeniy Shemyakin, Maria Vladimirtseva, Nikolay Egorov, Viacheslav Gabyshev, Yujin Kim, Sun-Hak Lee, Andrew Y. Cho, Deok-Hwan Kim, Tae-Hyeon Kim, Chang-Seon Song, Hyesung Jeong, Weonhwa Jheong, Yoonjee Hong, Junki Mine, Yuko Uchida, Ryota Tsunekuni, Takehiko Saito, Alexander Shestopalov   +23 more
doaj   +1 more source

Transition between immune and disease states in a cellular automaton model of clonal immune response

, 1997
In this paper we extend the Celada-Seiden (CS) model of the humoral immune response to include infectious virus and cytotoxic T lymphocytes (cellular response).
Abbas, Boon, Britton, Celada, Celada, Celada, Danielak, Farmer, Fishman, Franco Celada, Grossman, Guckenheimer, Hiernaux, Hiernaux, Karunaweera, Kaufman, Lawrence, Lippert, Lo, Michele Bezzi, Morel, Morpurgo, Philip E. Seiden, Romagnani, Romball, Stefano Ruffo, Wolfram   +26 more
core   +2 more sources

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Genotype Sequencing and Phylogenetic Analysis Revealed the Origins of Citrus Yellow Vein Clearing Virus California Isolates

Viruses
The Citrus yellow vein clearing virus (CYVCV) causes a viral disease that has been reported in some citrus-growing regions in countries in Eurasia including Pakistan, India, Türkiye, Iran, China, and South Korea.
Yong-Duo Sun, Raymond Yokomi
doaj   +1 more source

Assessing sequence plasticity of a virus-like nanoparticle by evolution toward a versatile scaffold for vaccines and drug delivery [PDF]

, 2015
Yuan Lu, Wei Mun Chan, Benjamin Y. Ko, Christopher C. VanLang, James R. Swartz   +4 more
openalex   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Anti-influenza A virus restriction factors that shape the human species barrier and virus evolution. [PDF]

PLoS Pathog, 2023
Petric PP, Schwemmle M, Graf L.
europepmc   +1 more source