Biochemical characterization of novel retroviral integrase proteins. [PDF]
PLoS ONE, 2013 Integrase is an essential retroviral enzyme, catalyzing the stable integration of reverse transcribed DNA into cellular DNA. Several aspects of the integration mechanism, including the length of host DNA sequence duplication flanking the integrated ...
Allison Ballandras-Colas +4 more
doaj +11 more sources
SurVirus: a repeat-aware virus integration caller [PDF]
Nucleic Acids Research, 2021 Abstract A significant portion of human cancers are due to viruses integrating into human genomes. Therefore, accurately predicting virus integrations can help uncover the mechanisms that lead to many devastating diseases. Virus integrations can be called by analysing second generation high-throughput sequencing datasets.
Yi Zhou +8 more
openaire +3 more sources
Characteristics of Hepatitis B virus integration and mechanism of inducing chromosome translocation [PDF]
npj Genomic Medicine, 2023 Hepatitis B virus (HBV) integration is closely associated with the onset and progression of tumors. This study utilized the DNA of 27 liver cancer samples for high-throughput Viral Integration Detection (HIVID), with the overarching goal of detecting HBV
Xiaofang Cui +5 more
doaj +2 more sources
The Telomeric Repeats of Human Herpesvirus 6A (HHV-6A) Are Required for Efficient Virus Integration. [PDF]
PLoS Pathogens, 2016 Human herpesvirus 6A (HHV-6A) and 6B (HHV-6B) are ubiquitous betaherpesviruses that infects humans within the first years of life and establishes latency in various cell types.
Nina Wallaschek +6 more
doaj +6 more sources
A Cell Culture System to Investigate Marek’s Disease Virus Integration into Host Chromosomes [PDF]
Microorganisms, 2021 Marek’s disease virus (MDV) is a highly oncogenic alphaherpesvirus that causes a devastating neoplastic disease in chickens. MDV has been shown to integrate its genome into the telomeres of latently infected and tumor cells, which is crucial for ...
Yu You +6 more
doaj +2 more sources
Integration of a virus membrane protein into the lipid bilayer of target cells as a prerequisite for immune cytolysis [PDF]
, 1979 Structural requirements for membrane antigens on target cells to mediate immune cytolysis were studied in a model system with purified membrane proteins from Semliki Forest virus (SFV). These SFV spike proteins were isolated in the form of detergent- and
Barz, D. +3 more
core +3 more sources
Persistence of intrahepatic hepatitis B virus DNA integration in patients developing hepatocellular carcinoma after hepatitis B surface antigen seroclearance [PDF]
Clinical and Molecular Hepatology, 2021 Background/Aims The role of hepatitis B virus (HBV) integration into the host genome in hepatocarcinogenesis following hepatitis B surface antigen (HBsAg) seroclearance remains unknown.
Jeong Won Jang +9 more
doaj +1 more source
Journal of Virology, 2004 ABSTRACT It had been suggested that during integration of spumaretroviruses (foamy viruses) the right (U5) end of the cDNA is processed, while the left (U3) remains uncleaved. We confirmed this hypothesis by sequencing two-long terminal repeat (LTR) circle junctions of unintegrated DNA.
Matthias Rammling +12 more
openaire +3 more sources
Dengue Virus Pathogenesis: an Integrated View [PDF]
Clinical Microbiology Reviews, 2009 SUMMARYMuch remains to be learned about the pathogenesis of the different manifestations of dengue virus (DENV) infections in humans. They may range from subclinical infection to dengue fever, dengue hemorrhagic fever (DHF), and eventually dengue shock syndrome (DSS).
Penelope Koraka +2 more
openaire +4 more sources
Retroviral DNA integration: ASLV, HIV, and MLV show distinct target site preferences. [PDF]
PLoS Biology, 2004 The completion of the human genome sequence has made possible genome-wide studies of retroviral DNA integration. Here we report an analysis of 3,127 integration site sequences from human cells.
Rick S Mitchell +7 more
doaj +1 more source