Characteristics of Hepatitis B virus integration and mechanism of inducing chromosome translocation [PDF]
npj Genomic Medicine, 2023 Hepatitis B virus (HBV) integration is closely associated with the onset and progression of tumors. This study utilized the DNA of 27 liver cancer samples for high-throughput Viral Integration Detection (HIVID), with the overarching goal of detecting HBV
Xiaofang Cui +5 more
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A Cell Culture System to Investigate Marek’s Disease Virus Integration into Host Chromosomes [PDF]
Microorganisms, 2021 Marek’s disease virus (MDV) is a highly oncogenic alphaherpesvirus that causes a devastating neoplastic disease in chickens. MDV has been shown to integrate its genome into the telomeres of latently infected and tumor cells, which is crucial for ...
Yu You +6 more
doaj +2 more sources
Hepatitis B virus integration and hepatocarcinogenesis [PDF]
Liver ResearchHepatitis B virus (HBV) is the most common cause of hepatocellular carcinoma (HCC), which is the predominant liver cancer type in Southeast Asia. Approximately 350 million individuals suffer from persistent hepatitis B infection worldwide.
Linlin Ma +3 more
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Detecting virus integration sites based on multiple related sequencing data by VirTect [PDF]
BMC Medical Genomics, 2019 Background Since tumor often has a high level of intra-tumor heterogeneity, multiple tumor samples from the same patient at different locations or different time points are often sequenced to study tumor intra-heterogeneity or tumor evolution.
Yuchao Xia +3 more
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DeepVISP: Deep Learning for Virus Site Integration Prediction and Motif Discovery
Advanced Science, 2021 Approximately 15% of human cancers are estimated to be attributed to viruses. Virus sequences can be integrated into the host genome, leading to genomic instability and carcinogenesis.
Haodong Xu, Peilin Jia, Zhongming Zhao
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DeepHBV: a deep learning model to predict hepatitis B virus (HBV) integration sites [PDF]
BMC Ecology and Evolution, 2021 Background The hepatitis B virus (HBV) is one of the main causes of viral hepatitis and liver cancer. HBV integration is one of the key steps in the virus-promoted malignant transformation.
Canbiao Wu +14 more
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Hepatitis B viral DNA integration occurs within three days of infection and is enhanced by ATR inhibition [PDF]
Tumour Virus ResearchChronic hepatitis B virus (HBV) infection is a major risk factor for hepatocellular carcinoma, with viral DNA integration into the host genome playing a pivotal role in oncogenesis.
Dong Li +10 more
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Persistence of intrahepatic hepatitis B virus DNA integration in patients developing hepatocellular carcinoma after hepatitis B surface antigen seroclearance [PDF]
Clinical and Molecular Hepatology, 2021 Background/Aims The role of hepatitis B virus (HBV) integration into the host genome in hepatocarcinogenesis following hepatitis B surface antigen (HBsAg) seroclearance remains unknown.
Jeong Won Jang +9 more
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The Telomeric Repeats of Human Herpesvirus 6A (HHV-6A) Are Required for Efficient Virus Integration. [PDF]
PLoS Pathogens, 2016 Human herpesvirus 6A (HHV-6A) and 6B (HHV-6B) are ubiquitous betaherpesviruses that infects humans within the first years of life and establishes latency in various cell types.
Nina Wallaschek +6 more
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Retroviral DNA integration: ASLV, HIV, and MLV show distinct target site preferences. [PDF]
PLoS Biology, 2004 The completion of the human genome sequence has made possible genome-wide studies of retroviral DNA integration. Here we report an analysis of 3,127 integration site sequences from human cells.
Rick S Mitchell +7 more
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