Results 111 to 120 of about 635,324 (372)
HIV gene expression from intact proviruses positioned in bacterial artificial chromosomes at integration sites previously identified in latently infected T cells [PDF]
, 2011 HIV integration predominantly occurs in introns of transcriptionally active genes. To study the impact of the integration site on HIV gene expression, a complete HIV-1 provirus (with GFP as a fusion with Nef) was inserted into bacterial artificial ...
Eipers, Peter G. +2 more
core +1 more source
A Discrete-time Networked Competitive Bivirus SIS Model [PDF]
arXiv, 2023 The paper deals with the analysis of a discrete-time networked competitive bivirus susceptible-infected-susceptible (SIS) model. More specifically, we suppose that virus 1 and virus 2 are circulating in the population and are in competition with each other.
arxiv
FEBS Open Bio, EarlyView.This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi +2 more
wiley +1 more source
Avian immunoglobulin-producing cell lines [PDF]
, 1991 The present invention involves a method for preparing antibody-producing chicken cell clones. This method comprises a series of steps including initially immunizing a first chicken with a desired antigen.
Humphries, Eric H.
core +1 more source
FEBS Open Bio, EarlyView.ICP34.5 is one of the most important antihost response proteins. The saRNA‐encoding HSV‐1 neurovirulence protein ICP34.5 clearly mediated the eukaryotic initiation factor 2 alpha subunit (eIF2α) dephosphorylation and significant suppression of innate immune responses in vitro, leading to enhanced expression of the saRNA‐encoded gene.
Xuemin Lu +6 more
wiley +1 more source
International Journal of Genomics, 2016 Chromosomal fragile sites (FSs) are loci where gaps and breaks may occur and are preferential integration targets for some viruses, for example, Hepatitis B, Epstein-Barr virus, HPV16, HPV18, and MLV vectors.
Juliana Gonçalves +5 more
doaj +1 more source
Comparative study of adenosine 3′‐pyrophosphokinase domains of MuF polymorphic toxins
FEBS Open Bio, EarlyView.With the ultimate goal of understanding the association of toxin‐immunity modules to temperate phages, we characterized toxins from three prophages and examined cross‐protection from immunity proteins. The toxins exhibit adenosine 3′‐pyrophosphokinase activity and are toxic in Escherichia coli.
Eloïse M. Paulet +6 more
wiley +1 more source
Identification and extensive analysis of inverted-duplicated HBV integration in a human hepatocellular carcinoma cell line [PDF]
BMB Reports, 2012 Hepatitis B virus (HBV) DNA is often integrated intohepatocellular carcinoma (HCC). Although the relationshipbetween HBV integration and HCC development has beenwidely studied, the role of HBV integration in HCCdevelopment is still not completely ...
Jeong Bok1,#, Kwang Joong Kim1,#, Mi-Hyun Park1, Seung-Hak Cho2, Hye-Ja Lee1, Eun-Ju Lee1, Chan Park1 & Jong-Young Lee1,*
doaj
The R263K Dolutegravir Resistance-Associated Substitution Progressively Decreases HIV-1 Integration
mBio, 2017 Human immunodeficiency virus (HIV) infection persists despite decades of active antiretroviral therapy (ART), effectively preventing viral eradication. Treatment decreases plasma viral RNA, but viral DNA persists, mostly integrated within the genome of ...
Thibault Mesplède +6 more
doaj +1 more source
FEBS Open Bio, EarlyView.Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran +3 more
wiley +1 more source