Results 131 to 140 of about 194,914 (262)

RNA‐Micelles as Self‐Assembling Structures for Efficient Co‐Delivery of Synergistic siRNA and Nucleoside Analogues to Treat CRC Lung Metastasis

Advanced Functional Materials, EarlyView.
Two kinds of self‐assembled RNA micelles were used to co‐deliver synergistic siRNA and nucleoside analogues for the treatment of colorectal cancer lung metastases. Near‐complete elimination of lung cancer metastases was confirmed in an orthotopic lung metastasis model constructed using human colorectal cancer lung metastases patient surgical samples to
Kai Jin, Piotr Rychahou, Daniel W. Binzel, B. Mark Evers, Peixuan Guo   +4 more
wiley   +1 more source

INTERVENTION EFFECT OF THE INTEGRATION MODEL ON NEGATIVE EMOTIONS OF ADOLESCENTS DURING THE OUTBREAK OF CORONA VIRUS DISEASE 2019

, 2021
Jun Chen, Sang Guo-qiang, Yu Zhang, Aifeng Jiang   +3 more
openalex   +1 more source

High‐Resolution Characterization of Protein‐Conjugated, mRNA‐Loaded Lipid Nanoparticles by Analytical Ultracentrifugation

Advanced Functional Materials, EarlyView.
Lipid nanoparticles containing messenger RNA are characterized by sedimentation velocity analytical ultracentrifugation using UltraScan's new Custom Grid algorithm to provide multi‐dimensional distributions for partial specific volume (particle density), molar mass, sedimentation, diffusion, and hydrodynamic radius.
Sophia Bird, Connor Smith, Nahal Habibi, Samantha Rivera, Saeed Mortezazadeh, Reece Martin, Benjamin M. Geilich, Gilles Besin, Borries Demeler   +8 more
wiley   +1 more source

Friend leukemia virus integration 1 activates the Rho GTPase pathway and is associated with metastasis in breast cancer

, 2015
Wei Song, Wěi Li, Lingyu Li, Shilin Zhang, Yan Xu, Wen Xue, Xiaoying Zhang, Huimin Tian, Ailing Li, Ji‐Fan Hu, Jiuwei Cui   +10 more
openalex   +2 more sources

Dual‐Layer Living Hydrogel Enables On‐Demand Delivery of Phages and Probiotics for Synergistic Wound Infection Therapy

Advanced Functional Materials, EarlyView.
A dual‐layer living hydrogel, ProΦGel, integrates bacteriophages and probiotics for synergistic wound infection therapy. The outer gelatin‐based matrix releases phages on demand in response to P. aeruginosa infections, while inner alginate beads sustain probiotic delivery.
Siyuan Tao, Darine D'Adam, Anna Hu, Sixuan Zhang, Josua Roduner, Katharina Maniura‐Weber, Qun Ren   +6 more
wiley   +1 more source

Amyloidogenic Peptide Fragments Designed From Bacterial Collagen‐like Proteins Form Hydrogel

Advanced Functional Materials, EarlyView.
This study identified amyloidogenic sequence motifs in bacterial collagen‐like proteins and exploited these to design peptides that self‐assemble into β‐sheet fibers and form hydrogels. One hydrogel supported healthy fibroblast growth, showing promise for biocompatible materials. Our work demonstrates that bacterial sequences can be harnessed to create
Vamika Sagar, Xuen J Ng, Lukas Lechel, Ashish Chand Rajwar, Hendrik Bargel, Abhishek A. Jalan   +5 more
wiley   +1 more source

Hypoxic exposure activates the B cell-specific Moloney murine leukaemia virus integration site 1/PI3K/Akt axis and promotes EMT in leukaemia stem cells. [PDF]

Oncol Lett, 2021
Jiang M, He G, Li J, Li J, Guo X, Gao J.
europepmc   +1 more source

The mode of hepatitis B virus DNA integration in chromosomes of human hepatocellular carcinoma. [PDF]

, 1987
Tsutomu Nagaya, Toru Nakamura, Takashi Tokino, Toshiki Tsurimoto, Masayuki Imai, Tadanori Mayumi, Kouzin Kamino, Kazuhiko Yamamura, Keiko Matsubara   +8 more
openalex   +1 more source

Supplementary Tables from The D2 and D3 Sublineages of Human Papilloma Virus 16–Positive Cervical Cancer in Guatemala Differ in Integration Rate and Age of Diagnosis

, 2023
Hong Lou, Joseph F. Boland, Edmundo Torres-González, Anaseidy Albanez, Weiyin Zhou, Mia Steinberg, Léna Diaw, Jason Mitchell, David A. Roberson, Michael J. Cullen, L. Henry Garland, Sara Bass, Robert D. Burk, Meredith Yeager, Nicolas Wentzensen, Mark Schiffman, Enrique Alvirez Freites, Eduardo Gharzouzi, Lisa Mirabello, Michael Dean   +19 more
openalex   +1 more source

Generation of an Induced Pluripotent Stem Cell‐Derived Alveolar Type II In Vitro Model to Study Influenza A Virus Infection and Drug Treatments

Advanced Healthcare Materials, EarlyView.
Patient‐specific induced pluripotent stem cells (iPSCs) can be differentiated into alveolar type II cells (iAT2s), expanded as 3D alveolospheres, and grown at physiologically relevant air–liquid interface (ALI). This study shows for the first time the infectability of iAT2s by the influenza A virus (IAV) and proves their responsiveness to the well ...
Lena Gauthier, Hristina Koceva, Yann Bachelot, Rosanne W. Koutstaal, Puck B. van Kasteren, Marc Thilo Figge, Christian Eggeling, Alexander Sandy Mosig   +7 more
wiley   +1 more source