Results 141 to 150 of about 635,324 (372)
Viral Proteins U41 and U70 of Human Herpesvirus 6A Are Dispensable for Telomere Integration
Viruses, 2018 Human herpesvirus-6A and -6B (HHV-6A and -6B) are two closely related betaherpesviruses that infect humans. Upon primary infection they establish a life-long infection termed latency, where the virus genome is integrated into the telomeres of latently ...
Darren J. Wight +5 more
doaj +1 more source
Journal of General Virology, 2008 Fowlpox virus (FWPV) is found worldwide in poultry and wild birds. FWPV is a natural example of recombination between viruses, as reticuloendotheliosis virus (REV) fragments have been found in all poultry FWPVs and these are implicated in virulence alteration.
Irena Shkoda, Irit Davidson, Shimon Perk
openaire +3 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Despite the availability of effective therapies for Multiple Sclerosis (MS), the unpredictable nature of disease progression and the variability in individual treatment outcomes call for reliable biomarkers. This pilot study aims to investigate the potential of plasma circulating microRNAs (miRNAs) as predictive biomarkers for ...
Fortunata Carbone +19 more
wiley +1 more source
Insights into Hepatitis B Virus DNA Integration-55 Years after Virus Discovery
The Innovation, 2020 Hepatitis B virus (HBV), which was discovered in 1965, is a threat to global public health. HBV infects human hepatocytes and leads to acute and chronic liver diseases, and there is no cure.
Kaitao Zhao, Andrew Liu, Yuchen Xia
doaj
Natural resistance of banana genotypes to banana streak virus is probably driven by transcriptional gene silencing [PDF]
, 2012 The genome of banana (Musa sp.) harbours multiple integrations of Banana streak virus (BSV), whereas this badnavirus does not require integration for the replication of its ds DNA genome.
Baurens, Franc-Christophe +6 more
core
Progress in the use of adeno-associated viral vectors for gene therapy [PDF]
, 2004 The development of safe and efficient gene transfer vectors is crucial for the success of gene therapy trials. A viral vector system promising to meet these requirements is based on the apathogenic adeno-associated virus (AAV-2), a member of the ...
Braun-Falco, M., Buning, H., Hallek, M.
core +1 more source
Prevalent and Disseminated Recombinant and Wild-Type Adeno-Associated Virus Integration in Macaques and Humans. [PDF]
Hum Gene Ther, 2023 Martins KM +6 more
europepmc +1 more source
Reduction and Hamiltonian aspects of a model for virus-tumour interaction in oncolytic virotherapy [PDF]
arXiv, 2019 We analyse the Hamiltonian structure of a system of first-order ordinary differential equations used for modeling the interaction of an oncolytic virus with a tumour cell population. The analysis is based on the existence of a Jacobi Last Multiplier for the system and a time dependent first integral. For suitable conditions on the model parameters this
arxiv
Identification of Repurposable Drugs and Adverse Drug Reactions for Various Courses of COVID-19 Based on Single-Cell RNA Sequencing Data [PDF]
arXiv, 2020 Coronavirus disease 2019 (COVID-19) has impacted almost every part of human life worldwide, posing a massive threat to human health. There is no specific drug for COVID-19, highlighting the urgent need for the development of effective therapeutics. To identify potentially repurposable drugs, we employed a systematic approach to mine candidates from U.S.
arxiv
Advanced Biology, EarlyView.Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi +4 more
wiley +1 more source