Results 11 to 20 of about 635,324 (372)

Prototype development of the integral-field unit for VIRUS [PDF]

SPIE Proceedings, 2006
VIRUS is a planned integral-field instrument for the Hobby-Eberly Telescope (HET). In order to achieve a large field-of-view and high grasp at reasonable costs, the approach is to replicate integral-field units (IFU) and medium sized spectrographs many times.
Andreas Kelz, Povilas Palunas, Phillip J. MacQueen, Martin M. Roth, Frank Grupp, Ute Tripphahn, Svend M. Bauer, Gary J. Hill, Emil Popow   +8 more
openaire   +4 more sources

Evaluating the state of the science for adeno-associated virus integration: An integrated perspective [PDF]

Molecular Therapy, 2022
On August 18, 2021, the American Society of Gene and Cell Therapy (ASGCT) hosted a virtual roundtable on adeno-associated virus (AAV) integration, featuring leading experts in preclinical and clinical AAV gene therapy, to further contextualize and understand this phenomenon.
Denise E. Sabatino, Frederic D. Bushman, Randy J. Chandler, Ronald G. Crystal, Beverly L. Davidson, Ricardo Dolmetsch, Kevin C. Eggan, Guangping Gao, Irene Gil-Farina, Mark A. Kay, Douglas M. McCarty, Eugenio Montini, Adora Ndu, Jing Yuan   +13 more
openaire   +4 more sources

Detecting virus integration sites based on multiple related sequencing data by VirTect [PDF]

BMC Medical Genomics, 2019
Background Since tumor often has a high level of intra-tumor heterogeneity, multiple tumor samples from the same patient at different locations or different time points are often sequenced to study tumor intra-heterogeneity or tumor evolution.
Yuchao Xia, Yun Liu, Minghua Deng, Ruibin Xi   +3 more
doaj   +2 more sources

A Graph Based Framework to Model Virus Integration Sites [PDF]

Computational and Structural Biotechnology Journal, 2016
With next generation sequencing thousands of virus and viral vector integration genome targets are now under investigation to uncover specific integration preferences and to define clusters of integration, termed common integration sites (CIS), that may allow to assess gene therapy safety or to detect disease related genomic features such as oncogenes.
Fronza, Raffaele, VASCIAVEO, ALESSANDRO, BENSO, Alfredo, Schmidt, Manfred   +3 more
openaire   +5 more sources

BS-virus-finder: virus integration calling using bisulfite sequencing data [PDF]

GigaScience, 2017
Abstract Background DNA methylation plays a key role in the regulation of gene expression and carcinogenesis. Bisulfite sequencing studies mainly focus on calling single nucleotide polymorphism, different methylation region, and find allele-specific DNA methylation.
Gao, Shengjie, Hu, Xuesong, Xu, Fengping, Gao, Changduo, Xiong, Kai, Zhao, Xiao, Chen, Haixiao, Zhao, Shancen, Wang, Mengyao, Fu, Dongke, Zhao, Xiaohui, Bai, Jie, Mao, Likai, Li, Bo, Wu, Song, Wang, Jian, Li, Shengbin, Yang, Huangming, Bolund, Lars, Pedersen, Christian N. S.   +19 more
openaire   +6 more sources

Role of the multiple telomeric repeat arrays in integration, persistence, and efficacy of the commercial CVI988 vaccine [PDF]

mSphere
Marek’s disease virus (MDV) is a highly oncogenic alphaherpesvirus that causes fatal T cell lymphomas in chickens. Oncogenic MDV strains can integrate their genome into the host telomeres of latently infected and tumor cells.
Luca D. Bertzbach, Yu You, Tereza Vychodil, Ahmed Kheimar, Lisa Kossak, Mohammad A. Sabsabi, Andelé M. Conradie, Benedikt B. Kaufer   +7 more
doaj   +2 more sources

Virusplot: a web server for viral integration analysis and visualization [PDF]

Frontiers in Oncology
The integration of viral DNA into the human genome is a critical event in the pathogenesis of various cancers. This process leads to genomic instability, disrupts cellular regulatory mechanisms, and activates oncogenes or inactivates tumor suppressor ...
Erqiang Hu, Erqiang Hu, Erqiang Hu, Jianhong An, Jianhong An, Jianhong An, Adam J Gersten, Adam J Gersten, Nicole Wu, Nicole Kawachi, Jing Zhu, Gregory Rosenblatt, Stelby Augustine, Richard V. Smith, Jeffrey E Segall, Harry Ostrer, Antonio L Amelio, Antonio L Amelio, Christine H. Chung, Michael B. Prystowsky, Thomas J. Ow, Thomas J. Ow, Wenjun Deng, Shanye Yin, Shanye Yin, Shanye Yin   +25 more
doaj   +2 more sources

Characterization of Equine Infectious Anemia Virus Integration in the Horse Genome [PDF]

Viruses, 2015
Human immunodeficiency virus (HIV)-1 has a unique integration profile in the human genome relative to murine and avian retroviruses. Equine infectious anemia virus (EIAV) is another well-studied lentivirus that can also be used as a promising retro ...
Qiang Liu, Xue-Feng Wang, Jian Ma, Xi-Jun He, Xiao-Jun Wang, Jian-Hua Zhou   +5 more
doaj   +2 more sources

An Integrated Sequencing Approach for Updating of Pseudorabies Virus Transcriptome [PDF]

Pathogens, 2020
In the last couple of years, the implementation of long-read sequencing (LRS) technologies for transcriptome profiling has uncovered an extreme complexity of viral gene expression. In this study, we carried out a systematic analysis on the pseudorabies virus transcriptome by combining our current data obtained by using Pacific Biosciences Sequel and ...
Zsolt Csabai, Dóra Tombácz, Dóra Tombácz, Michael Snyder, Gábor Torma, Zoltán Deim, Zsolt Boldogkői, Dániel Göbhardter   +7 more
openaire   +5 more sources

Virus removal and integrity in aged RO membranes [PDF]

Water Research, 2016
Membrane ageing reduces the quality of the filtered water. Therefore, in order to warrant public health, monitoring membrane performances are of utmost importance. Reverse osmosis (RO) membranes are generally used to remove viruses and salt. However, there is no detailed study demonstrating the impact of aged membrane on the rejection of viruses and of
Dominique Patureau, Marie-Laure Pype, Bogdan C. Donose, Llucia Marti, Wolfgang Gernjak, Wolfgang Gernjak, Wolfgang Gernjak, Nathalie Wéry   +7 more
openaire   +5 more sources