Results 11 to 20 of about 194,914 (262)

Biochemical characterization of novel retroviral integrase proteins. [PDF]

PLoS ONE, 2013
Integrase is an essential retroviral enzyme, catalyzing the stable integration of reverse transcribed DNA into cellular DNA. Several aspects of the integration mechanism, including the length of host DNA sequence duplication flanking the integrated ...
Allison Ballandras-Colas, Hema Naraharisetty, Xiang Li, Erik Serrao, Alan Engelman   +4 more
doaj   +1 more source

Hepatitis B Virus DNA Integration Drives Carcinogenesis and Provides a New Biomarker for HBV-related HCCSummary

Cellular and Molecular Gastroenterology and Hepatology, 2023
Hepatitis B virus (HBV) DNA integration is an incidental event in the virus replication cycle and occurs in less than 1% of infected hepatocytes during viral infection.
Shiou-Hwei Yeh, Chiao-Ling Li, You-Yu Lin, Ming-Chih Ho, Ya-Chun Wang, Sheng-Tai Tseng, Pei-Jer Chen   +6 more
doaj   +1 more source

Male preference for TERT alterations and HBV integration in young-age HBV-related HCC: implications for sex disparity [PDF]

Clinical and Molecular Hepatology
Background/Aims Hepatocellular carcinoma (HCC) exhibits significant sex disparities in incidence, yet its molecular mechanisms remain unclear. We explored the role of telomerase reverse transcriptase (TERT) genetic alterations and hepatitis B virus (HBV)
Jin Seoub Kim, Hye Seon Kim, Kwon Yong Tak, Ji Won Han, Heechul Nam, Pil Soo Sung, Sung Won Lee, Jung Hyun Kwon, Si Hyun Bae, Jong Young Choi, Seung Kew Yoon, Jeong Won Jang   +11 more
doaj   +1 more source

Genotipificación, niveles de expresión y estado físico del virus del papiloma humano en pacientes colombianos con cáncer de células escamosas en la cavidad oral

Biomédica: revista del Instituto Nacional de Salud, 2016
Introducción. Uno de los factores de riesgo del carcinoma de células escamosas en la cavidad oral es la infección por el virus del papiloma humano (HPV), cuyas prevalencias dependen de la región geográfica. Objetivo.
Alveiro Erira, Leidy Angélica Motta, Andrés Chala, Andrey Moreno, Fredy Gamboa, Dabeiba Adriana García   +5 more
doaj   +1 more source

Impact of Host Telomere Length on HHV-6 Integration

Viruses, 2022
Human herpesvirus 6A and 6B are two closely related viruses that infect almost all humans. In contrast to most herpesviruses, HHV-6A/B can integrate their genomes into the telomeres during the infection process.
Darren J. Wight, Giulia Aimola, Georg Beythien, Louis Flamand, Benedikt B. Kaufer   +4 more
doaj   +1 more source

Retroviral DNA integration: viral and cellular determinants of target-site selection. [PDF]

PLoS Pathogens, 2006
Retroviruses differ in their preferences for sites for viral DNA integration in the chromosomes of infected cells. Human immunodeficiency virus (HIV) integrates preferentially within active transcription units, whereas murine leukemia virus (MLV ...
Mary K Lewinski, Masahiro Yamashita, Michael Emerman, Angela Ciuffi, Heather Marshall, Gregory Crawford, Francis Collins, Paul Shinn, Jeremy Leipzig, Sridhar Hannenhalli, Charles C Berry, Joseph R Ecker, Frederic D Bushman   +12 more
doaj   +1 more source

Multiple HPV integration mode in the cell lines based on long-reads sequencing

Frontiers in Microbiology, 2023
BackgroundThe integration of human papillomavirus (HPV) is closely related to the occurrence of cervical cancer. However, little is known about the complete state of HPV integration into the host genome.MethodsIn this study, three HPV-positive cell lines,
Xiaofang Cui, Xiaofang Cui, Yiyan Li, Chuanpeng Zhang, Yanwei Qi, Yuhui Sun, Weiyang Li, Weiyang Li   +7 more
doaj   +1 more source

HBV DNA Integration: Molecular Mechanisms and Clinical Implications

Viruses, 2017
Chronic infection with the Hepatitis B Virus (HBV) is a major cause of liver-related morbidity and mortality. One peculiar observation in cells infected with HBV (or with closely‑related animal hepadnaviruses) is the presence of viral DNA integration in ...
Thomas Tu, Magdalena A. Budzinska, Nicholas A. Shackel, Stephan Urban   +3 more
doaj   +1 more source

HPV integration profiling using nanopore sequencing and association with cervical precancerous lesion

Frontiers in Microbiology
ObjectivesHPV infection and HPV DNA integration can lead to cervical cancer, but the relationship with lesion severity is unclear. This study aimed to investigate the correlation between HPV integration profile and cervical lesion extent.Materials and ...
Ying Hou, Shoufeng Ni, Xin Liu, Xingyu Liu, Nan Wang, Fuqiang Xu, Jianyong Gao, Yanmei Li, Yuxiang Zhou, Huadong Tang, Meina Bian, Xiulan Li, Lili Zhang, Weiwei Wang, Qing Liu   +14 more
doaj   +1 more source

Insights into Hepatitis B Virus DNA Integration-55 Years after Virus Discovery

The Innovation, 2020
Hepatitis B virus (HBV), which was discovered in 1965, is a threat to global public health. HBV infects human hepatocytes and leads to acute and chronic liver diseases, and there is no cure.
Kaitao Zhao, Andrew Liu, Yuchen Xia
doaj   +1 more source