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Biomédica: revista del Instituto Nacional de Salud, 2016 Introducción. Uno de los factores de riesgo del carcinoma de células escamosas en la cavidad oral es la infección por el virus del papiloma humano (HPV), cuyas prevalencias dependen de la región geográfica. Objetivo.
Alveiro Erira +5 more
doaj +1 more source
DeepVISP: Deep Learning for Virus Site Integration Prediction and Motif Discovery
Advanced Science, 2021 Approximately 15% of human cancers are estimated to be attributed to viruses. Virus sequences can be integrated into the host genome, leading to genomic instability and carcinogenesis.
Haodong Xu, Peilin Jia, Zhongming Zhao
doaj +1 more source
The landscape of viral associations in human cancers [PDF]
, 2020 Here, as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, for which whole-genome and—for a subset—whole-transcriptome sequencing data from 2,658 cancers across 38 tumor types was aggregated, we systematically investigated potential ...
Alawi, Malik +14 more
core +3 more sources
Male preference for TERT alterations and HBV integration in young-age HBV-related HCC: implications for sex disparity [PDF]
Clinical and Molecular HepatologyBackground/Aims Hepatocellular carcinoma (HCC) exhibits significant sex disparities in incidence, yet its molecular mechanisms remain unclear. We explored the role of telomerase reverse transcriptase (TERT) genetic alterations and hepatitis B virus (HBV)
Jin Seoub Kim +11 more
doaj +1 more source
Impact of Host Telomere Length on HHV-6 Integration
Viruses, 2022 Human herpesvirus 6A and 6B are two closely related viruses that infect almost all humans. In contrast to most herpesviruses, HHV-6A/B can integrate their genomes into the telomeres during the infection process.
Darren J. Wight +4 more
doaj +1 more source
Retroviral DNA integration: viral and cellular determinants of target-site selection. [PDF]
PLoS Pathogens, 2006 Retroviruses differ in their preferences for sites for viral DNA integration in the chromosomes of infected cells. Human immunodeficiency virus (HIV) integrates preferentially within active transcription units, whereas murine leukemia virus (MLV ...
Mary K Lewinski +12 more
doaj +1 more source
Adeno-associated virus integration: virus versus vector [PDF]
Gene Therapy, 2008 Although a large percentage of the world population is seropositive for exposure to various strains of adeno-associated virus (AAV), a human parvovirus, AAV has never been identified as an etiologic agent of human disease. Most likely contributing to the pronounced lack of pathogenicity is the fact that AAV is a naturally defective virus that requires ...
openaire +3 more sources
Multiple HPV integration mode in the cell lines based on long-reads sequencing
Frontiers in Microbiology, 2023 BackgroundThe integration of human papillomavirus (HPV) is closely related to the occurrence of cervical cancer. However, little is known about the complete state of HPV integration into the host genome.MethodsIn this study, three HPV-positive cell lines,
Xiaofang Cui +7 more
doaj +1 more source
Virus-Clip: a fast and memory-efficient viral integration site detection tool at single-base resolution with annotation capability [PDF]
, 2008 Viral integration into the human genome upon infection is an important risk factor for various human malignancies. We developed viral integration site detection tool called Virus-Clip, which makes use of information extracted from soft-clipped sequencing
Ho, DWH, Ng, IOL, Sze, MF
core +3 more sources
The Infectious Disease Ontology in the Age of COVID-19 [PDF]
, 2021 The Infectious Disease Ontology (IDO) is a suite of interoperable ontology modules that aims to provide coverage of all aspects of the infectious disease domain, including biomedical research, clinical care, and public health.
Babcock, Shane +3 more
core +1 more source