Results 51 to 60 of about 635,324 (372)

DeepHBV: a deep learning model to predict hepatitis B virus (HBV) integration sites

BMC Ecology and Evolution, 2021
Background The hepatitis B virus (HBV) is one of the main causes of viral hepatitis and liver cancer. HBV integration is one of the key steps in the virus-promoted malignant transformation.
Canbiao Wu, Xiaofang Guo, Mengyuan Li, Jingxian Shen, Xiayu Fu, Qingyu Xie, Zeliang Hou, Manman Zhai, Xiaofan Qiu, Zifeng Cui, Hongxian Xie, Pengmin Qin, Xuchu Weng, Zheng Hu, Jiuxing Liang   +14 more
doaj   +1 more source

Recombinant Adeno-associated Virus Transduction and Integration

Molecular Therapy, 2008
Recombinant adeno-associated virus (rAAV) holds promise as a gene therapy vector for a multitude of genetic disorders such as hemophilia, cystic fibrosis, and the muscular dystrophies. Given the variety of applications and tissue types toward which these vectors may be targeted, an understanding of rAAV transduction is crucial for the effective ...
Brian R Schultz, Jeffrey S. Chamberlain
openaire   +3 more sources

Towards an integrated molecular model of plant–virus interactions [PDF]

Current Opinion in Virology, 2012
The application in recent years of network theory methods to the study of host-virus interactions is providing a new perspective to the way viruses manipulate the host to promote their own replication. An integrated molecular model of such pathosystems require three detailed maps describing, firstly, the interactions between viral elements, secondly ...
Santiago F. Elena, Guillermo Rodrigo, Guillermo Rodrigo   +2 more
openaire   +5 more sources

Integrative functional genomics decodes herpes simplex virus 1 [PDF]

Nature Communications, 2020
AbstractThe predicted 80 open reading frames (ORFs) of herpes simplex virus 1 (HSV-1) have been intensively studied for decades. Here, we unravel the complete viral transcriptome and translatome during lytic infection with base-pair resolution by computational integration of multi-omics data.
Whisnant, Adam W., Jürges, Christopher S., Hennig, Thomas, Wyler, Emanuel, Prusty, Bhupesh, Rutkowski, Andrzej J., L’hernault, Anne, Djakovic, Lara, Göbel, Margarete, Döring, Kristina, Menegatti, Jennifer, Antrobus, Robin, Matheson, Nicholas J., Künzig, Florian W. H., Mastrobuoni, Guido, Bielow, Chris, Kempa, Stefan, Liang, Chunguang, Dandekar, Thomas, Zimmer, Ralf, Landthaler, Markus, Grässer, Friedrich, Lehner, Paul J., Friedel, Caroline C., Erhard, Florian, Dölken, Lars   +25 more
openaire   +9 more sources

HPV integration profiling using nanopore sequencing and association with cervical precancerous lesion

Frontiers in Microbiology
ObjectivesHPV infection and HPV DNA integration can lead to cervical cancer, but the relationship with lesion severity is unclear. This study aimed to investigate the correlation between HPV integration profile and cervical lesion extent.Materials and ...
Ying Hou, Shoufeng Ni, Xin Liu, Xingyu Liu, Nan Wang, Fuqiang Xu, Jianyong Gao, Yanmei Li, Yuxiang Zhou, Huadong Tang, Meina Bian, Xiulan Li, Lili Zhang, Weiwei Wang, Qing Liu   +14 more
doaj   +1 more source

Accurate Detection of HPV Integration Sites in Cervical Cancer Samples Using the Nanopore MinION Sequencer Without Error Correction

Frontiers in Genetics, 2020
During the carcinogenesis of cervical cancer, the DNA of human papillomavirus (HPV) is frequently integrated into the human genome, which might be a biomarker for the early diagnosis of cervical cancer.
Wenjuan Yang, Ying Liu, Ruyi Dong, Jia Liu, Jidong Lang, Jialiang Yang, Weiwei Wang, Jingjing Li, Bo Meng, Geng Tian, Geng Tian   +10 more
doaj   +1 more source

Directed DNA shuffling of retrovirus and retrotransposon integrase protein domains. [PDF]

PLoS ONE, 2013
Chimeric proteins are used to study protein domain functions and to recombine protein domains for novel or optimal functions. We used a library of chimeric integrase proteins to study DNA integration specificity.
Xiaojie Qi, Edwin Vargas, Liza Larsen, Whitney Knapp, G Wesley Hatfield, Richard Lathrop, Suzanne Sandmeyer   +6 more
doaj   +1 more source

Integrase residues that determine nucleotide preferences at sites of HIV-1 integration: implications for the mechanism of target DNA binding [PDF]

, 2014
Retroviruses favor target-DNA (tDNA) distortion and particular bases at sites of integration, but the mechanism underlying HIV-1 selectivity is unknown. Crystal structures revealed a network of prototype foamy virus (PFV) integrase residues that distort ...
Cherepanov, Peter, Engelman, Alan, Krishnan, Lavanya, Li, Xiang, Maertens, Goedele N., Serrao, Erik, Shun, Ming-Chieh   +6 more
core   +1 more source

The BET Family of Proteins Targets Moloney Murine Leukemia Virus Integration near Transcription Start Sites

Cell Reports, 2013
A hallmark of retroviral replication is integration of the viral genome into host cell DNA. This characteristic makes retrovirus-based vectors attractive delivery vehicles for gene therapy.
Jan De Rijck, Christine de Kogel, Jonas Demeulemeester, Sofie Vets, Sara El Ashkar, Nirav Malani, Frederic D. Bushman, Bart Landuyt, Steven J. Husson, Katrien Busschots, Rik Gijsbers, Zeger Debyser   +11 more
doaj   +1 more source

Viral Hybrid Vectors for Somatic Integration - Are They the Better Solution? [PDF]

, 2009
The turbulent history of clinical trials in viral gene therapy has taught us important lessons about vector design and safety issues. Much effort was spent on analyzing genotoxicity after somatic integration of therapeutic DNA into the host genome. Based
Ehrhardt, Anja, Müther, Nadine, Noske, Nadja   +2 more
core   +4 more sources