Results 61 to 70 of about 635,324 (372)
The context-specificity of virulence evolution revealed through evolutionary invasion analysis [PDF]
arXiv, 2023 Models are often employed to integrate knowledge about epidemics across scales and simulate disease dynamics. While these approaches have played a central role in studying the mechanics underlying epidemics, we lack ways to reliably predict how the relationship between virulence (the harm to hosts caused by an infection) and transmission will evolve in
arxiv
BMC Genomics, 2004 Background Plant genomes contain various kinds of repetitive sequences such as transposable elements, microsatellites, tandem repeats and virus-like sequences.
Kishima Yuji +5 more
doaj +1 more source
Peptides derived from HIV-1 integrase that bind Rev stimulate viral genome integration. [PDF]
PLoS ONE, 2009 BACKGROUND: The human immunodeficiency virus type 1 (HIV-1) integrase protein (IN), catalyzes the integration of viral DNA into the host cell genome. IN catalyzes the first step of the integration process, namely the 3'-end processing in which IN removes
Aviad Levin +5 more
doaj +1 more source
Site-specific integration by adeno-associated virus. [PDF]
Proceedings of the National Academy of Sciences, 1996 Adeno-associated virus (AAV) has attracted considerable interest as a potential vector for gene delivery. Wild-type virus is notable for the lack of association with any human disease and the ability to stably integrate its genome in a site-specific manner in a locus on human chromosome 19 (AAVS1).
C Giraud +4 more
openaire +2 more sources
Common Viral Integration Sites Identified in Avian Leukosis Virus-Induced B-Cell Lymphomas
mBio, 2015 Avian leukosis virus (ALV) induces B-cell lymphoma and other neoplasms in chickens by integrating within or near cancer genes and perturbing their expression.
James F. Justice +2 more
doaj +1 more source
VIRUS TRAFFIC OF PANDEMIC: Integrative Science Perspective
Shautut Tarbiyah, 2020 This paper aims to narrate ontological status in the context of empiric and metaphysic realisms as the integral and interdependent paradigms through Karl Raimun Popper's version of deductive phenomenology approach.The existence of pandemic virus not only booms greatly mysteriously that is strongly worrying about the life of contemporary society, but ...
Sarpin Sarpin +5 more
openaire +3 more sources
FEBS Letters, EarlyView.Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma +8 more
wiley +1 more source
Cellular and Molecular Gastroenterology and Hepatology, 2023 Hepatitis B virus (HBV) DNA integration is an incidental event in the virus replication cycle and occurs in less than 1% of infected hepatocytes during viral infection.
Shiou-Hwei Yeh +6 more
doaj
Viruses, 2022 Allosteric integrase (IN) inhibitors (ALLINIs), which are promising preclinical compounds that engage the lens epithelium-derived growth factor (LEDGF)/p75 binding site on IN, can inhibit different aspects of human immunodeficiency virus 1 (HIV-1 ...
Parmit Kumar Singh +5 more
doaj +1 more source
Avian oncogenesis induced by lymphoproliferative disease virus: a neglected or emerging retroviral pathogen? [PDF]
, 2014 Lymphoproliferative disease virus (LPDV) is an exogenous oncogenic retrovirus that induces lymphoid tumors in some galliform species of birds. Historically, outbreaks of LPDV have been reported from Europe and Israel.
Allison, Andrew B +13 more
core +1 more source