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Pseudorabies virus latency: restricted transcription
Archives of Virology, 1990Cloned pseudorabies virus (PRV) sequences representing over 80% of the viral genome were radiolabeled and individually hybridized to nucleic acid in the trigeminal ganglia of acutely and latently infected swine. In acutely infected animals, all cloned probes hybridized to PRV RNA and DNA.
J R, Lokensgard +2 more
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2001
MDV latency is defined as the persistence of the viral genome in the absence of production of infectious virus except during reactivation. A number of systems for studying MDV latency exist, and most involve the use of lymphoblastoid cells or tumors. It has been difficult to divorce latency and transformation.
R W, Morgan +6 more
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MDV latency is defined as the persistence of the viral genome in the absence of production of infectious virus except during reactivation. A number of systems for studying MDV latency exist, and most involve the use of lymphoblastoid cells or tumors. It has been difficult to divorce latency and transformation.
R W, Morgan +6 more
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Expert Reviews in Molecular Medicine, 2003
Herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) are ubiquitous human pathogens. They share with other herpesviruses the ability to establish lifelong latent infection of the host. Periodic reactivation from latency is responsible for most of the clinical disease burden of HSV infection.
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Herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) are ubiquitous human pathogens. They share with other herpesviruses the ability to establish lifelong latent infection of the host. Periodic reactivation from latency is responsible for most of the clinical disease burden of HSV infection.
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Subclinical herpes virus reactivation and latency
Current Opinion in Infectious Diseases, 1998Although there has been considerable refinement in our understanding of the processes underlying the establishment and maintenance of latency, important research questions remain. Results from various workers imply that the establishment of latency may be a dynamic process and may offer possible therapeutic targets.
R, Patel, D R, Harper
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Herpes Simplex Virus Latency after Direct Ganglion Virus Inoculation
Journal of Neurovirology, 1998Herpes simplex virus (HSV) latent infection of ganglion neurons follows axoplasmic transport of HSV, probably in the form of nucleocapsid from peripheral sites of infection (e.g. footpad). This raises the possibility that latency is dependent on this particular means of presenting HSV to ganglion neurons.
K A, Hay +3 more
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1984
The restriction patterns of genomes of twelve different field isolates of PrV were analyzed. All were found to differ. In most cases, the basis of the differences in restriction patterns was found to lie in the acquisition or deletion of sequences which appear to be nonessential to the productive infection of RK cells. Mutagenesis of a laboratory virus
Tamar Ben-Porat +5 more
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The restriction patterns of genomes of twelve different field isolates of PrV were analyzed. All were found to differ. In most cases, the basis of the differences in restriction patterns was found to lie in the acquisition or deletion of sequences which appear to be nonessential to the productive infection of RK cells. Mutagenesis of a laboratory virus
Tamar Ben-Porat +5 more
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Reactivation of Epstein-Barr virus from latency
Reviews in Medical Virology, 2005The general problem in cancer treatment centres on finding agents that specifically affect cancer cells without damaging normal cells. The differences between cancer cells and normal cells are usually very subtle but about 15% of all human cancers involve a virus infection, for example the Epstein-Barr virus associated cancers.
Wolfgang, Amon, Paul J, Farrell
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Neuronal Control of Herpes Simplex Virus Latency
Virology, 1993Herpes simplex virus (HSV) is a common neurotropic virus, and latent infection of sensory ganglion neurons readily occurs in humans and in experimentally infected animals. During HSV latency, infectious virus and viral antigen are not detected, and HSV transcription is limited to specific RNA termed latency-associated transcript (LAT).
R B, Tenser, W A, Edris, K A, Hay
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A murine model of pseudorabies virus latency
Microbial Pathogenesis, 1992The mouse is a useful laboratory animal for studying various aspects of pseudorabies virus (PRV) virulence. Mice are highly susceptible hosts for PRV infection and are unable to survive acute viral infection. Because of this, mouse models have not been useful for studying PRV latent infections.
F A, Osorio, D L, Rock
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Latency and the tumour virus problem
Journal of Theoretical Biology, 1976Abstract Virus-cell relationships in latency and the association between oncogenic viruses and transformed cells have been compared in the light of Theobald Smith's dictum that “a damaging parasite tends to become a symbiont when the relationship between it, and its native host, has existed long”. This may be particularly significant in consideration
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