Results 101 to 110 of about 778,919 (247)

Escherichia coli-derived virus-like particles in vaccine development

npj Vaccines, 2017
Recombinant virus-like particle-based vaccines are composed of viral structural proteins and mimic authentic native viruses but are devoid of viral genetic materials. They are the active components in highly safe and effective vaccines for the prevention
Xiaofen Huang, Xin Wang, Jun Zhang, N. Xia, Qinjian Zhao   +4 more
semanticscholar   +1 more source

Virus-like particles in vaccine development

Expert Review of Vaccines, 2010
Virus-like particles (VLPs) are multiprotein structures that mimic the organization and conformation of authentic native viruses but lack the viral genome, potentially yielding safer and cheaper vaccine candidates. A handful of prophylactic VLP-based vaccines is currently commercialized worldwide: GlaxoSmithKline's Engerix (hepatitis B virus) and ...
António, Roldão, Maria Candida M, Mellado, Leda R, Castilho, Manuel J T, Carrondo, Paula M, Alves   +4 more
openaire   +2 more sources

Applying lessons from human papillomavirus vaccines to the development of vaccines against Chlamydia trachomatis

Expert Review of Vaccines, 2018
Introduction: Chlamydia trachomatis (Ct), the most common bacterial sexually transmitted infection (STI), leads to pelvic inflammatory disease, infertility, and ectopic pregnancy in women.
Kathryn M. Frietze, Rebeccah Lijek, Bryce Chackerian   +2 more
doaj   +1 more source

Nucleocapsid Protein of Newcastle Disease Virus as an Antigenic Carrier [PDF]

, 2002
Newcastle disease virus (NDV) is an economically important avian virus that causes loss to the poultry industry. It has a wide host range infecting 27 of the 50 orders of birds. Generally, the virus consists of six structural proteins: nucleocapsid (NP)
Rabu, Amir
core  

Zika Virus Baculovirus-Expressed Virus-Like Particles Induce Neutralizing Antibodies in Mice

Virologica Sinica, 2018
The newly emerged mosquito-borne Zika virus (ZIKV) strains pose a global challenge owing to its ability to cause microcephaly and neurological disorders.
Shiyu Dai, Zhang Tao, Yanfang Zhang, Huálín Wáng, F. Dèng   +4 more
semanticscholar   +1 more source

Identification of Gastroenteric Viruses by Electron Microscopy Using Higher Order Spectral Features [PDF]

, 2005
Background: Many paediatric illnesses are caused by viral agents, for example, acute gastroenteritis. Electron microscopy can provide images of viral particles and can be used to identify the agents.
Chandran, Vinod, Ong, Chien
core   +2 more sources

Octahedral small virus-like particles of dengue virus type 2

Journal of Virology
Flavivirus envelope (E) and precursor M (prM) proteins, when ectopically expressed, assemble into empty, virus-like particles (VLPs). Cleavage of prM to M and loss of the pr fragment converts the VLPs from immature to mature particles, mimicking a ...
Adam Johnson, Martín Dodes Traian, Richard M. Walsh, Simon Jenni, Stephen C. Harrison   +4 more
doaj   +1 more source

Combining high-resolution cryo-electron microscopy and mutagenesis to develop cowpea mosaic virus for bionanotechnology

, 2017
Particles of cowpea mosaic virus (CPMV) have enjoyed considerable success as nanoparticles. The development of a system for producing empty virus-like particles (eVLPs) of the virus, which are non-infectious and have the potential to be loaded with ...
Alex Durrant, Aljabali, Dalsgaard, Emma L. Hesketh, George P. Lomonossoff, Goddard, Hesketh, Hesketh,, Huynh, Jaafar,, Johnson, Kimanius, Lin, Lin, Lomonossoff, Lomonossoff, Montague, Neil A. Ranson, Porta, Porta, Rae, Sainsbury, Sainsbury, Sainsbury, Saunders, Singh, Steele, Steinmetz, Taylor, Taylor, Usha, Wen, Yulia Meshcheriakova   +32 more
core   +1 more source

Templated mineralization by charge-modified cowpea mosaic virus [PDF]

, 2013
Templated mineralization of virus particles provides routes to narrowly dispersed nanoparticles that are not readily prepared by other means. The templated mineralization of metal or metal oxide on the external surface of wild-type cowpea mosaic virus ...
Aljabali, Alaa A A, Evans, David J.
core   +2 more sources

Plug-and-Display: decoration of Virus-Like Particles via isopeptide bonds for modular immunization

Scientific Reports, 2016
Virus-like particles (VLPs) are non-infectious self-assembling nanoparticles, useful in medicine and nanotechnology. Their repetitive molecularly-defined architecture is attractive for engineering multivalency, notably for vaccination.
Karl D. Brune, D. Leneghan, Iona J Brian, A. Ishizuka, M. Bachmann, S. Draper, S. Biswas, M. Howarth   +7 more
semanticscholar   +1 more source