Results 111 to 120 of about 1,054,067 (301)

Adaptation of H9N2 Influenza Viruses to Mammalian Hosts: A Review of Molecular Markers

, 2020
As the number of human infections with avian and swine influenza viruses continues to rise, the pandemic risk posed by zoonotic influenza viruses cannot be underestimated.
Jessica A. Belser, Xiangjie Sun, Taronna R. Maines   +2 more
core   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Optimization of the antiviral spectrum of cyclophilin inhibitors targeting respiratory viruses

Antimicrobial Agents and Chemotherapy
We evaluated the antiviral activity of a library of 36 urea-based small-molecule cyclophilin inhibitors (SMCypIs) against human respiratory syncytial virus (hRSV) and human metapneumovirus (hMPV).
Laurent Softic, Bryan Jimenez-Araya, Nazim Ahnou, Maxime Duval, Quentin Nevers, Rozenn Brillet, Jean-Francois Guichou, Christophe Rodriguez, Patrice Bruscella, Jean-Michel Pawlotsky, Slim Fourati, Abdelhakim Ahmed-Belkacem   +11 more
doaj   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Epidemiological characteristics and genomic analysis of respiratory adenovirus in Lanzhou City from 2023 to 2025

Frontiers in Cellular and Infection Microbiology
ObjectiveHuman adenoviruses (HAdVs) are common pathogens causing inflammation in the upper respiratory tract, lungs, conjunctiva, urinary tract, and gastrointestinal tract.
Biao Wang, Biao Wang, Shu Liang, Huan Wei, Miao Wang, Xiaoshu Zhang, Xiaoshu Zhang, Maoxing Dong, Hui Zhang   +8 more
doaj   +1 more source

Viruses [PDF]

Proceedings of the Royal Society of Medicine, 1946
openaire   +2 more sources

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Spill-Over of Avian and Human Influenza a Viruses to Swine in Egypt and Lebanon

Zoonotic Diseases
Pigs play a key role in the ecology of influenza A viruses (IAVs), particularly in avian influenza (AI)-endemic regions where co-circulation of viruses from different hosts increases reassortment risk.
Mokhtar R. Gomaa, Jessica Yazbek, Mounir Abi-Said, Basma Elsaadani, Dalia Zahra, Hager Emam, Mina Nabil Kamel, Basant Helal, Ahmed El Taweel, Omnia Kutkat, Mohamed GabAllah, Ahmed Kayed, Deesse Tabet, Pamela P. McKenzie, Richard J. Webby, Mohamed A. Ali, Rabeh El-Shesheny, Ghazi Kayali   +17 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source