Results 141 to 150 of about 64,402 (239)

Novel Flavonoid Senotherapeutics Identified by Phenotypic Drug Discovery Reduce Senescence and Improve Multiple Markers of Healthspan

open access: yesAging Cell, Volume 25, Issue 10, October 2026.
Phenotypic screening and SAR‐guided drug design identified two flavonoid‐derived senolytics, SR29384 and SR31133, which selectively killed different types of senescent cells more efficiently and with greater selectivity than fisetin in culture. In aged and progeroid mice, these fisetin analogs reduced tissue senescence and improved physical function ...
Lei Justan Zhang   +17 more
wiley   +1 more source

Complications and outcomes of standing flank versus ventral midline laparotomy for equine nephrosplenic entrapment

open access: yesEquine Veterinary Education, Volume 38, Issue 10, Page e736-e743, October 2026.
Summary Background Nephrosplenic entrapment (NSE) is a common surgical colic in horses. Ventral midline laparotomy (VML) under general anaesthesia (GA) is the standard approach, whereas standing flank laparotomy (SFL) is an alternative approach for surgical correction. However, direct comparisons between these approaches are lacking.
V. Santalucia   +5 more
wiley   +1 more source

Outcomes of Kaposi sarcoma in people living with HIV who maintain long‐term viral suppression: A prospective case‐series

open access: yesHIV Medicine, Volume 27, Issue 10, Page 1715-1721, October 2026.
Abstract Background Data on chemotherapeutic efficacy and tolerability for Kaposi Sarcomas (KS) in people living with HIV (PWH) and HIV‐virological control are limited. We aimed to describe clinical responses and tolerability of KS therapies in PWH with HIV‐aviraemic KS in a prospective cohort.
S. Bacquart   +10 more
wiley   +1 more source

Traditional Chinese Medicine Formulas in Delaying Aging: From Theoretical Foundations to Molecular Mechanisms and Translational Perspectives

open access: yesJournal of Cellular and Molecular Medicine, Volume 30, Issue 19, October 2026.
ABSTRACT Aging is a systemic decline in physiological integrity, driving chronic diseases such as neurodegeneration, cardiovascular disorders, and metabolic syndromes. Rapid global population aging urgently demands effective interventions. Traditional Chinese medicine (TCM) formulas, characterized by multi‐component, multi‐target, and multi‐pathway ...
Chenrong Jin   +10 more
wiley   +1 more source

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