Results 71 to 80 of about 6,595,942 (260)

Tumor Exposomics: A New Paradigm for Individualized Continuous Exposure Monitoring

Advanced Science, EarlyView.
Tumor exposomics integrates continuous monitoring of environmental exposures, endogenous biological responses, and behavioral factors within a unified temporal framework. By combining multimodal sensing technologies with AI‐enabled causal modeling, this emerging paradigm reconstructs exposure‐damage trajectories and supports individualized dynamic risk
Kaicheng Shen, Weiyi Wang, Yang Wang, Yiqiang Wu, Xiaohong Liu, Wei Zhang, Juanjuan Ou   +6 more
wiley   +1 more source

Mitochondria‐Targeted Nanotherapeutics: A Promising Strategy in Modulating Mitochondrial Function, Transfer, and Transplantation

Advanced Science, EarlyView.
This review summarizes the pathogenic role of mitochondria in diseases and highlights mitochondrial transfer and transplantation as emerging therapeutic strategies. It systematically discusses how nanomaterials are engineered to facilitate these processes, and critically examines the current challenges and future perspectives for their clinical ...
Yuanyuan Su, Zhiyan Gong, Jiao Mu, Lili Huang, Pengfei Yang, Chenli Zhang, Lingshan Zhao, Liling Yang, Jun Deng, Xiaohui Liao   +9 more
wiley   +1 more source

Effects of sex and race on the changes in intrahepatic lipid, total and visceral adipose tissue in response to exercise training in obese adolescents [PDF]

, 2013
BACKGROUD: Non-alcoholic fatty liver is the most frequent liver abnormality observed in obese children and adolescents. It is has yet to be determined whether sex and race plays a role in the effect of regular exercise without calorie restriction on ...
Deldin, Anthony
core  

Brain Network Dynamics of Local and Global Predictive Processing in Aging

Advanced Science, EarlyView.
Separation of concurrent whole‐brain networks in source‐reconstructed magnetoencephalography (MEG) data suggests that healthy aging reorganizes, rather than uniformly attenuates, neural responses elicited from hierarchical auditory violations. Enhanced early sensory deviance processing alongside reduced higher‐order cognitive responses suggests a large‐
Mathias Houe Andersen, Gemma Fernández‐Rubio, David R. Quiroga‐Martinez, Mattia Rosso, Mathias Klarlund, Kit Melissa Larsen, Hartwig Roman Siebner, Morten L. Kringelbach, Peter Vuust, Leonardo Bonetti   +9 more
wiley   +1 more source

A quantified risk-scoring system including the visceral fat area for peritoneal metastasis of gastric cancer

, 2019
Xiaodong Chen,1,* Weisheng Chen,2,* Yunshi Huang,2 Jingxuan Xu,1 Yunpeng Zeng,1 Mingming Shi,2 Libin Xu,2 Weiteng Zhang,2 Guanbao Zhu,2 Chenchen Mao,1 Xian Shen1,21Department of Gastrointestinal Surgery, The Second Affiliated Hospital, Wenzhou Medical ...
Xu L, Zhang W, Shi M, Huang Y, Mao C, Chen W, Chen X, Zeng Y, Zhu G, Shen X, Xu J   +10 more
core  

Measurement of visceral fat: should we include retroperitoneal fat? [PDF]

, 2014
OBJECTIVE: Whether retroperitoneal fat should be included in the measurement of visceral fat remains controversial. We compared the relationships of fat areas in peritoneal, retroperitoneal, and subcutaneous compartments to metabolic syndrome, adipokines,
Chung-Yi Yang, Jen-Kuang Lee, Shyang-Rong Shih (662601), Hung-Ren Hsieh, Jen-Kuang Lee (170504), Pi-Hua Liu, Jou-Wei Lin, Chung-Yi Yang (343307), Shyang-Rong Shih, Pi-Hua Liu (73581), Jung-Nan Wei (662603), Hung-Ren Hsieh (662599), Chi-Sheng Hung, Jou-Wei Lin (210430), Wen-Ya Ma (662600), Jyh-Ming Liou (662602), Jyh-Ming Liou, Hung-Yuan Li, Lee-Ming Chuang, Lee-Ming Chuang (215892), Ming-Fong Chen, Hung-Yuan Li (662604), Ming-Fong Chen (309336), Mao-Shin Lin, Jung-Nan Wei, Mao-Shin Lin (309335), Wen-Ya Ma, Chi-Sheng Hung (405362)   +27 more
core   +1 more source

Degrading GPX4 via Biomimetic Nanoparticle‐Mediated In Situ Synthesis of Deep‐Learning‐Designed Binder‐Degron Chimeras for Prostate Cancer Therapy

Advanced Science, EarlyView.
A deep‐learning‐designed binder is fused to a combinatorial degron to create a binder‐degron chimera (bdC) that recruits the CUL2‐RING ubiquitin ligase complex. Encapsulation in a prostate‐cancer‐targeted, CD47‐camouflaged nanocarrier enables tumor‐specific in situ bdC expression, triggering GPX4 degradation and ferroptosis, thereby establishing a ...
Si‐Han Zhang, Ye An, Na Zeng, Mei‐Cheng Liu, Jian‐Xuan Sun, Xi Gong, Jin‐Zhou Xu, Shao‐Gang Wang, Qi‐Dong Xia   +8 more
wiley   +1 more source

Consumption of different types of bakery products and its effect on visceral fat area in healthy population

Roczniki Panstwowego Zakladu Higieny, 2018
Background. Bread is one of the world’s most consumed food commodity. However, in the last years consumption of bread and bakery products has declined, especially in the Western population. The reason for concern is the weight gain and presence of gluten
Martina Gažarowa, Petra Lenártová, Jana Kopčeková, Jana Mrázová, Maria Holovičová, Zuzana Chlebová, Joanna Wyka   +6 more
doaj   +1 more source

Changing pattern of visceral leishmaniasis, United Kingdom, 1985-2004. [PDF]

, 2006
A 20-year (1985-2004) retrospective review of 39 patients with imported visceral leishmaniasis found that tourism to Mediterranean countries and HIV infection were associated with visceral leishmaniasis. Diagnosis was often delayed.
Lawrence John, Anthony D.M. Bryceson, Bruceson, Anthony DM, Diana N.J. Lockwood, Aeesha N.J. Malik, Lockwood, Diana NJ, Malik, Aeesha NJ, John, Lawrence   +7 more
core   +1 more source

CXCL3 Antagonism Reverses Systemic Antitumor Immune Memory Impairment Associated With High Tumor Burden and Sensitizes Anti‐PD‐1 Therapy

Advanced Science, EarlyView.
This study reveals that large tumors secrete more chemokine CXCL3, which recruits immunosuppressive neutrophils to the periphery, thereby impairing the activation and memory of systemic tumor‑reactive CD8+ T cells. CXCL3 antagonism restores systemic immune memory and enhances the antitumor efficacy of anti‑PD‑1 therapy, offering a potential strategy to
Ji Wang, Xinyu Tang, Zeju Li, Qi Qi, Chang Sun, Wen Sun, Weiya Zhang, Yue Yin, Ya Deng, Peiwen Ling, Yifan Xu, Guangshun Sun, Yi Ren, Hong Pan, Shui Wang, Wenbin Zhou   +15 more
wiley   +1 more source