Results 61 to 70 of about 200,246 (317)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Social Research: An International Quarterly, 2016 This paper gives an extended argument for the conclusion that values are visible properties in the world we inhabit (including nature) and are not entirely derivable from states of mind such as our desires and "moral sentiments." The argument thus repudiates as a superstition of modernity the widespread assumption that the concept of "nature" is to be ...
openaire +2 more sources
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Influence of Driver's Experience on Textual Traffic Sign Efficiency Depending on Visibility
Promet (Zagreb), 2012 The research objective is to study the influence of thedriver's experience on the efficiency of the textual traffic sign dependingon the visibility, that is on the weather conditions.
Senka Pašagić +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Application of Fuzzy Techniques for Determining the Operating Speed Based on Road Geometry
Promet (Zagreb), 2012 The operating speed is certainly one of the most important variables in the management of road safety. Its determination has been refined in the last few years by means of experimental analyses that have also sanctioned its strong link with the context ...
Antonino D'Andrea, Orazio Pellegrino
doaj +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Linked Color Imaging of Barrett’s Esophageal Adenocarcinoma: Effects on Visibility
Gastroenterology InsightsSince linked color imaging (LCI) has been reported to increase the color differences in Barrett’s esophageal adenocarcinoma (BA) compared to white light imaging (WLI), a comparison of the visibility scores of various imaging techniques for BA is ...
Masahiro Saito +10 more
doaj +1 more source
Safety, 2017 The underground mining industry, and some above ground operations, rely on the use of heavy equipment that articulates to navigate corners in the tight confines of the tunnels.
Nicholas Schwabe, Alison Godwin
doaj +1 more source