Results 51 to 60 of about 29,157 (264)

Atmospheric Visibility and PM10 as Indicators of New Particle Formation in an Urban Environment [PDF]

open access: yesEnvironmental Science & Technology, 2015
It is well-known that new particle formation (NPF) in the atmosphere is inhibited by pre-existing particles in the air that act as condensation sinks to decrease the concentration and, thus, the supersaturation of precursor gases. In this study, we investigate the effects of two parameters-atmospheric visibility, expressed as the particle backscatter ...
Jayaratne, Rohan   +2 more
openaire   +4 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

Quantifying Vertical Differences in Green Visibility in High‑Density Cities: A Voxel‑Based Analysis Method [PDF]

open access: yesThe International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences
Urban green spaces are important for residents’ physical and mental health, but green visibility is difficult to quantify in high-rise, high-density cities, especially across different height levels.
H. Wang, L. Liu, S. Zlatanova
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

Landscape Character and Quality Assessment Through Map-Based Visibility Indicators: A Case Study in Western Crete, Greece

open access: yesLand
Landscape Character Assessment (LCA) is increasingly used to support landscape-sensitive planning; however, existing approaches often lack an operational integration of visual perception and map-based indicators, particularly in complex Mediterranean ...
Georgios Lampropoulos   +2 more
doaj   +1 more source

Visibility graph analysis of the grains and oilseeds indices

open access: yesPhysica A: Statistical Mechanics and its Applications
16 pages, 9 ...
Hao-Ran Liu, Ming-Xia Li, Wei-Xing Zhou
openaire   +2 more sources

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

A Multi-Colour Lamp Indicator

open access: yesMeasurement + Control, 1972
Designs are presented of miniature indicators using either filament lamps or light emitting diodes of different colours showing at a common viewing window.
E F Hasler
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

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