Results 61 to 70 of about 137,910 (297)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Patients' satisfaction with residents' communication skills recorded through a visual analogue scale. [PDF]

, 2013
Patients' satisfaction with residents' communication skills recorded through a visual analogue scale.
Yves Libert (362278), Julie Meunier (362283), Darius Razavi (362286), Anne-Marie Etienne (362281), Jean-Louis Slachmuylder (362285), Isabelle Merckaert (362277), Aurore Liénard (362276), Isabelle Bragard (362279), Nicole Delvaux (362280), Christine Reynaert (362284), Serge Marchal (362282)   +10 more
core   +1 more source

Transform of visual analogue scale data and their clustering

International Journal of Knowledge Engineering and Soft Data Paradigms, 2011
We propose a hierarchical clustering for the visual analogue scale (VAS) in the framework of symbolic data analysis (SDA). The VAS is a method that can be readily understood by most people to measure a characteristic or attitude that cannot be directly measured.
Kotoe Katayama, Rui Yamaguchi, Seiya Imoto, Keiko Matsuura, Kenji Watanabe, Satoru Miyano   +5 more
openaire   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Qualifying thirst distress in the acute hospital setting – validation of a patient-reported outcome measure

Journal of Perioperative Nursing, 2021
Objective: This study aims to examine validity and sensitivity of two visual analogue scales (VASs), measuring thirst intensity and thirst distress, and compare them with a validated thirst discomfort scale (TDS).
Sharon Carey, Jacob Waller, Lucy Wang, Suzie Ferrie   +3 more
doaj   +1 more source

Vertical or horizontal visual analogue scales. [PDF]

Annals of the Rheumatic Diseases, 1979
Vertical and horizontal visual analogue scales have been compared in the measurement of pain. There was a good correlation between the 2 scales, but the scores from horizontal scales tended to be slightly lower than those from vertical scales.
J, Scott, E C, Huskisson
openaire   +2 more sources

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Are Asians comfortable with discussing death in health valuation studies? A study in multi-ethnic Singapore [PDF]

, 2006
BACKGROUND To characterize ease in discussing death (EID) and its influence on health valuation in a multi-ethnic Asian population and to determine the acceptability of various descriptors of death and "pits"/"all-worst" in health valuation ...
Wee, Hwee-Lin, Wee Hwee-Lin, Luo, X.H.Z.N., Cheung, Y.B., Cheung, Y.-B., Shu-Chuen Li, Nan Luo, Machin, David, Luo, N., Thumboo, Julian, Li Shu-Chuen, Julian Thumboo, Li, S.C., Fong, K.Y., Fong Kok-Yong, Wee, H.L., Li, Shu-Chuen, Xu-Hao Zhang, Cheung, Yin-Bun, Xie Feng, Luo, Nan, Wee, H.-L., Yin-Bun Cheung, Zhang, Xu-Hao, Cheung Yin-Bun, David Machin, Xie, F., Kok-Yong Fong, Machin David, Thumboo, J., Fong, Kok-Yong, Machin, D., Li, S.-C., Fong, K.-Y., Luo Nan, Xie, Feng, Thumboo Julian, Zhang, X.-H., Hwee-Lin Wee, Zhang Xu-Hao, Feng Xie   +40 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source