Results 71 to 80 of about 641,402 (266)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

UAV Visual Object Tracking Based on Spatio-Temporal Context

Drones
To balance the real-time and robustness of UAV visual tracking on a single CPU, this paper proposes an object tracker based on spatio-temporal context (STCT).
Yongxiang He, Chuang Chao, Zhao Zhang, Hongwu Guo, Jianjun Ma   +4 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Context flexibly modulates cue representations in visual cortex

Nature Communications
Learned sensory cues result in enhanced responses in sensory cortices and, in turn, enhanced responses draw attention towards cues in our environment that guide future decision making.
Alexa D. Faulkner, Alvin S. Chiu, Armin Sarabi, Swathi Karthik, Yaoxin S. Li, Christian R. Burgess   +5 more
doaj   +1 more source

The thinking eye: from Semir Zeki to John Onians

Comparatismi, 2017
In 1994 Semir Zeki’s neuro-aesthetics formalizes the interdisciplinary approach to aesthetic facts, linking scientifically the brain to creativity. Consequently, the history of art becomes a neuroarthistory of the human mind, defined as such in 2005 by ...
Denitza Roumenova Nedkova
doaj   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Co-lateralized bilingual mechanisms for reading in single and dual language contexts: evidence from visual half-field processing of action words in proficient bilinguals

Frontiers in Psychology, 2015
When reading, proficient bilinguals seem to engage the same cognitive circuits regardless of the language in use. Yet, whether or not such ‘bilingual’ mechanisms would be lateralized in the same way in distinct – single or dual – language contexts is a ...
Marlena eKrefta, Bartosz eMichałowski, Jacek eKowalczyk, Gregory eKroliczak   +3 more
doaj   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Visual Analysis of Citation Context-Based Article Influence Ranking

IEEE Access, 2019
Article influence ranking is an effective way to reduce information redundancy and improve the efficiency of article retrieval. A large number of ranking models for network items have been employed for the ranking of article influence, such as PageRank ...
Chen Shi, Haoxuan Wang, Binjie Chen, Yuhua Liu, Zhiguang Zhou   +4 more
doaj   +1 more source

Context-aware techniques for visualization

, 2010
Die Visualisierung von Daten wird immer wichtiger, da die Menge an Daten, ob gemessen oder berechnet, bereits enorme Ausmaße angenommen hat und oft nicht ohne geeignete Visualisierungsverfahren analysiert werden kann. Die Entwicklung neuartiger Methoden zur Darstellung von Daten, die es erlauben, ein tieferes Verständnis zu erlangen, ist noch immer ein
openaire   +2 more sources