Results 181 to 190 of about 280,553 (265)

Integrative Approaches to Treating Cellular Senescence in Kidney Disease

Advanced Science, EarlyView.
ABSTRACT Cellular senescence in the kidney plays a crucial role in the progression of acute kidney injury and chronic kidney disease. Therapeutic approaches targeting senescent cells, such as small molecule senolytic and senomorphic drugs, display efficacy in preclinical models.
Tomoka Misawa, Amruta A, LaTonya J. Hickson, Joy Wolfram   +3 more
wiley   +1 more source

Non-uniform contextual interactions in the visual cortex place fundamental limits on spatial vision. [PDF]

Cell Rep
Morton MP, Denagamage S, Hudson NV, Nandy AS.   +3 more
europepmc   +1 more source

Multimodal Layer‐Crossing Interrogation of Brain Circuits Enabled by Microfluidic Axialtrodes

Advanced Science, EarlyView.
The study introduces a flexible microfluidic axialtrode that integrates optical, electrical, and chemical modalities within a single polymer fiber. By redistributing electrodes and fluidic channels along the fiber axis via angled cleaving, it enables simultaneous optogenetic stimulation, electrophysiological recording, and drug delivery across brain ...
Kunyang Sui, Neela K. Codadu, Daman Rathore, Guanghui Li, Marcello Meneghetti, Anders L. Bøcker, Rune W. Berg, Rob C. Wykes, Christos Markos   +8 more
wiley   +1 more source

Quantitative Stain Mapping in X‐Ray Virtual Histology

Advanced Science, EarlyView.
Virtual histology promises 3D tissue examination without physical sectioning, yet has lacked the tissue‐specificity of conventional pathology. This work demonstrates the first quantitative three‐dimensional stain mapping at histologically relevant resolution, separating contrast agent from tissue to reveal cellular features such as nuclei. The approach
Dominik John, David M. Paganin, Marie‐Christine Zdora, Lisa Marie Petzold, Patrick Ilg, Junan Chen, Sara Baggio, Johannes B. Thalhammer, Sami Wirtensohn, Julian Moosmann, Jörg U. Hammel, Felix Beckmann, Samantha J. Alloo, Jannis N. Ahlers, Madleen Busse, Julia Herzen, Kaye S. Morgan   +16 more
wiley   +1 more source

Premature vision drives aberrant development of response properties in primary visual cortex. [PDF]

Elife
Griswold SV, Van Hooser SD.
europepmc   +1 more source

TRAP5 Inhibition Targeting Scar‐Associated Macrophages Ameliorates Acute Kidney Injury to Chronic Kidney Disease Transition

Advanced Science, EarlyView.
This study delineates macrophage heterogeneity along the acute kidney injury to chronic kidney disease transition. Single‐cell RNA sequencing reveals a TRAP5+ scar‐associated macrophage subset driven by Spp1–Cd44 signaling and mitochondrial metabolic reprogramming.
Chenxi Wang, Yaodong Gu, Wen Du, Lin Xie, Jinwei Quan, Yu Zhao, Ye Cheng, Zhaonan Wei, Yuanyuan Sha, Yi Wang, Dechao Xu, Xiang Gao, Min Chen, Xiangchen Gu   +13 more
wiley   +1 more source

Context flexibly modulates cue representations in visual cortex. [PDF]

Nat Commun
Faulkner AD, Chiu AS, Sarabi A, Karthik S, Li YS, Burgess CR.   +5 more
europepmc   +1 more source

High‐Resolution Multispectral Photovoltaic Imagers from Visible to Short‐Wave Infrared

Advanced Science, EarlyView.
We demonstrate a monolithic quad‐spectral imager that seamlessly integrates visible and short‐wave infrared detection on a single chip. Through direct photopatterning of an all‐polymer bulk heterojunction and colloidal quantum dots, the device achieves high‐resolution (640 × 512) imaging across 350–2400 nm, enabling multispectral capture for ...
Wanqing Li, Cheng Bi, Min He, Xiaolong Zheng, Yuning Luo, Yimei Tan, Chenxi Liu, Salihuojia Talanti, Yanfei Liu, Ge Mu, Qun Hao, Kangkang Weng, Xin Tang   +12 more
wiley   +1 more source

Predicting functional topography of the human visual cortex from cortical anatomy at scale

Ribeiro FL, Satzger R, Hoffstaedter F, Bürger C, Herholz P, Linhardt D, Benson NC, Schwarzkopf DS, Puckett AM, Bollmann S, Hebart MN.   +10 more
europepmc   +1 more source

Alpha-band echoes evoked by contrast and luminance changes emerge in and travel out from early visual cortex. [PDF]

J Vis
Morrow A, Turkovich E, Sankaran S, Pilipenko A, Samaha J.   +4 more
europepmc   +1 more source