Results 291 to 300 of about 2,870,855 (432)

Simultaneous Monitoring of Tyrosinase and ATP in Thick Brain Tissues Using a Single Two‐Photon Fluorescent Probe

open access: yesAdvanced Science, EarlyView.
A single dual‐emission two‐photon fluorescent probe is designed for simultaneously tracking tyrosinase (TYR) and adenosine triphosphate (ATP). With the help of this probe, the intricate correlation and regulatory mechanism between TYR and ATP during oxidative stress is uncovered.
Hong Huang   +12 more
wiley   +1 more source

Role of Testosterone Signaling in Microglia: A Potential Role for Sex‐Related Differences in Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
Testosterone enhances Aβ‐induced autophagy in microglia via the non‐genomic testosterone receptor GPRC6A, promoting Aβ clearance by suppressing ERK phosphorylation and inhibiting mTOR activation. In male 5xFAD mice, testicular removal reduces microglial autophagy and Aβ clearance, which is restored by testosterone.
Haiyan Du   +8 more
wiley   +1 more source

MODELS OF THE VISUAL CORTEX

open access: bronze, 1987
David Rose   +2 more
openalex   +1 more source

Exploring the Latent Information in Spatial Transcriptomics Data via Multi‐View Graph Convolutional Network Based on Implicit Contrastive Learning

open access: yesAdvanced Science, EarlyView.
STMIGCL is an implicit contrastive learning‐based multi‐view graph convolutional network framework designed for downstream tasks such as spatial domain recognition, trajectory inference, and spatially variable gene identification. By combining multi‐view learning with contrastive learning and employing contrastive learning methods that enhance contrast
Sheng Ren   +5 more
wiley   +1 more source

A column-like organization for ocular dominance in mouse visual cortex. [PDF]

open access: yesNat Commun
Goltstein PM   +3 more
europepmc   +1 more source

Neural Patterns of Social Pain in the Brain‐Wide Representations Across Social Contexts

open access: yesAdvanced Science, EarlyView.
Empathy arises from both physiological and social pain, yet their shared and context‐specific neural mechanisms remain unclear. Combining fMRI and multivariate pattern analysis, this study decodes overlapping empathy networks and distinct representations for social exclusion versus separation.
Xiaodong Zhang   +11 more
wiley   +1 more source

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