Results 311 to 320 of about 2,892,193 (407)
Lynch et al., identified novel targets on the wake‐promoting pathways that can effectively treat pain‐induced sleep disturbances. The authors demonstrated that Calcitonin gene‐related peptide‐expressing neurons (CGRP) in the external lateral parabrachial nucleus (PBelCGRP) serve as the primary relay node for pain stimuli that cause sleep disruption ...
Nicole Lynch+13 more
wiley +1 more source
Large-scale synaptic dynamics drive the reconstruction of binocular circuits in mouse visual cortex. [PDF]
Tsimring K+6 more
europepmc +1 more source
The chronic glutamate‐induced excitotoxicity hypothesis has profoundly informed the therapeutic strategies employed in Alzheimer’s disease (AD). This study shows pigment epithelium‐derived factor (PEDF) regulates astrocytic glutamate transporter‐1 (GLT‐1)‐mediated glutamate homeostasis and cognition. Reduced PEDF correlates with lower Mini‐Mental State
Jin‐Hui Shi+15 more
wiley +1 more source
Dynamic categorization rules alter representations in human visual cortex. [PDF]
Henderson MM+2 more
europepmc +1 more source
Uma base estrutural para a propriedade de orientação seletiva no cortex visual
Homero Mauricio Schneider
openalex +1 more source
Osteoblast‐CD4+ CTL Crosstalk Mediated by SIRT1/DAAM2 Axis Prevents Age‐Related Bone Loss
In the osteoblastic niche, SIRT1 activates and recruits CD4+ CTLs by increasing DAAM2 expression via EZH2 deacetylation and boosting the secretion of key chemokines, such as CCL3, CCL5, and CXCL10. Then, CD4+ CTL directly eliminates senescent osteoblasts in an MHC‐II‐dependent way, thereby slowing down the process of bone ageing and effectively ...
Bin Yang+20 more
wiley +1 more source
The pulvinar regulates plasticity in human visual cortex
Acquafredda M+5 more
europepmc +1 more source
Guided visual search is associated with target boosting and distractor suppression in early visual cortex. [PDF]
Duecker K+6 more
europepmc +1 more source
PRDM16 Reduces Cellular Senescence by Upregulating GSTM1
Cellular senescence drives aging and aging‐related organ disorders, yet PRDM16's role remains unexplored. This work uncovers that PRDM16 decreases significantly in aged organs, while its loss accelerates cellular senescence and aging‐related organ injury.
Qian Yuan+7 more
wiley +1 more source