Results 331 to 340 of about 2,870,855 (432)

Viridicatol from the Deep‐Sea‐Derived Fungus Alleviates Bone Loss by Targeting the Wnt/SHN3 Pathway

open access: yesAdvanced Science, EarlyView.
Viridicatol (VDC), isolated from the deep‐sea‐derived fungus, enhances osteogenesis in vitro and in vivo by targeting Wnt/SHN3 signaling pathway. It can be delivered via engineered nanovesicles to mitigate bone loss of osteoporosis, fracture repair, and osteogenesis imperfecta.
Chun‐Lan Xie   +10 more
wiley   +1 more source

Unveiling Multi‐Scale Architectural Features in Single‐Cell Hi‐C Data Using scCAFE

open access: yesAdvanced Science, EarlyView.
scCAFE is a deep learning framework designed to identify multi‐scale 3D genome architectural features from single‐cell Hi‐C data without dense imputation. It predicts chromatin loops, TAD‐like domains, and A/B compartments, enabling efficient characterization of organization at the single‐cell level. scCAFE also identifies marker loop anchors, offering
Fuzhou Wang   +12 more
wiley   +1 more source

Running modulates primate and rodent visual cortex differently. [PDF]

open access: yesElife
Liska JP   +6 more
europepmc   +1 more source

A Rapid Cortical Learning Process Supporting Students’ Knowledge Construction During Real Classroom Teaching

open access: yesAdvanced Science, EarlyView.
There is growing interest in understanding how classroom teaching works, but previous theories and studies leave a gap in the neurocognitive mechanisms involved in real classroom teaching. Here we show that during real classroom teaching, students' middle frontal cortex serves as a hub of a rapid cortical learning process, supporting their knowledge ...
Xiaodan Feng   +6 more
wiley   +1 more source

Principles of visual cortex excitatory microcircuit organization. [PDF]

open access: yesInnovation (Camb)
Chou CYC   +10 more
europepmc   +1 more source

Micro‐Coil Neuromodulation at Single‐Cell and Circuit Levels for Inhibiting Natural Neuroactivity, Neutralizing Electric Neural Excitation, and Suppressing Seizures

open access: yesAdvanced Science, EarlyView.
Micromagnetic stimulation (µMS) offers a precise method for neural inhibition, complementing existing neuromodulation techniques. Using an implantable micro‐coil device, µMS selectively suppresses cortical activity with high spatial resolution. It effectively counteracts micro‐electrode stimulation and reduces seizure amplitude, highlighting its ...
Kayeon Kim   +11 more
wiley   +1 more source

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