Results 191 to 200 of about 314,097 (252)

Lipid Nanoparticle Co‐Delivery of mRNA and a Small Molecule Drug for Oral Cancer Chemoimmunotherapy

Advanced Materials, EarlyView.
Co‐encapsulation of p53 mRNA and the small molecule ciclopirox within a lipid nanoparticle yields an all‐in‐one chemoimmunotherapy for oral squamous cell carcinoma. The platform engages caspase‐driven apoptosis in cancer cells while repolarizing tumor‐associated macrophages, achieving tumor reduction in both p53‐susceptible and p53‐resistant models and
Marshall S. Padilla, Jacqueline J. Li, Qunzhou Zhang, Korey Patwari, Shihong Shi, Hannah M. Yamagata, Ryann A. Joseph, Briyanna N. Hymms, Sridatta V. Teerdhala, Emily Fitzgerald, Ori Z. Chalom, Kushol Gupta, Mohamad‐Gabriel Alameh, Drew Weissman, Anh D. Le, Michael J. Mitchell   +15 more
wiley   +1 more source

Decoding the perceived value of Wushu short videos and its influencing factors: an interpretable machine learning analysis based on TikTok videos. [PDF]

Front Sports Act Living
Chen Y, Wu H, Xiang S.
europepmc   +1 more source

Mechanism‐Driven Nanoformulations for Cognitive Impairment Induced by Intermittent Hypoxia and Periodontitis

Advanced Materials, EarlyView.
Clinically, intermittent hypoxia (IH) is often accompanied by periodontitis, which accelerates cognitive impairment induced by IH. Novel Janus mesoporous gold‐silica nanoformulations (RVG‐Au&mSiO2‐TPP‐VB) enable intranasal delivery, achieve hierarchical targeting to neuronal mitochondria, effectively scavenge reactive oxygen species, inhibit the HIF‐1α/
Kai‐Run Zhang, Tianbao Zhu, An‐Qi Liu, Jia‐Jia Deng, Ya‐Li Han, Sheng‐Cai Qi, Xue Liu, Tian‐Yi Jiang, Ming‐Rui Zhai, Yu‐Ying He, Xiu‐Juan Li, Hong‐Ting Da, Rui Xu, Xiaomin Li, Jun Gao, Yue‐Hua Liu   +15 more
wiley   +1 more source

Severe fungal keratitis caused by <i>Lasiodiplodia theobromae</i> following grass trimmer-related ocular trauma: a case report. [PDF]

Med Mycol Case Rep
Mamat NS, Chua WC, Hussin I, Mohd Yusoff NS.   +3 more
europepmc   +1 more source

Resolving Heterogeneity of Targeted Lipid Nanoparticles Through Solution‐Based Biophysical Analyses

Advanced Materials, EarlyView.
AF4‐UV‐DLS‐MALS‐SAXS resolves previously inaccessible targeted lipid nanoparticle (tLNP) subpopulations that differ in size, shape, and composition. Correlation of subpopulation‐resolved biophysical properties with in vivo RNA delivery reveals that targeted placental transfection is associated with distinct tLNP subpopulations rather than ensemble ...
Hannah C. Geisler, Hannah C. Safford, Ajay S. Thatte, Marshall S. Padilla, Elisa Battistini, Hannah M. Yamagata, Violet M. Ullman, Alex Chan, Benjamin E. Nachod, Anushka Agrawal, Maxwell B. Watkins, Jesse B. Hopkins, Andrew Tsourkas, Kushol Gupta, Michael J. Mitchell   +14 more
wiley   +1 more source

Development and psychometric evaluation of an attitude scale on the use of new media technologies for teacher candidates - Turkish Form (ANMT-TC). [PDF]

BMC Psychol
Çay R, Güney E.
europepmc   +1 more source

Transcriptomic Analysis of Organotypic Porcine Retina Cultures. [PDF]

Int J Mol Sci
Khosravi S, Giorgio G, Staurenghi F, Schoenberger T, Gross P, Ried M, Frankenhauser J, Eder S, Markert E, Bakker RA, Babaei S, Zippel N.   +11 more
europepmc   +1 more source

Adjunctive povidone-iodine for <i>Acanthamoeba</i> keratitis: a randomized trial. [PDF]

Antimicrob Agents Chemother
Rajaraman R, Kassaye I, Sharma SS, Prajna NV, Lalitha P, Panigrahi A, Rammohan R, Aromin KM, Cook C, Porco TC, Lietman TM, Seitzman GD, Keenan JD.   +12 more
europepmc   +1 more source