Results 41 to 50 of about 1,674,843 (268)
Applied SciencesIndustry 4.0 produces large volumes of sensor and machine data, offering new possibilities for manufacturing analytics but also creating challenges in combining domain knowledge with visual analysis.
Adrian J. Böck +8 more
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egoDetect: Visual Detection and Exploration of Anomaly in Social Communication Network
Sensors, 2020 The development of the Internet has made social communication increasingly important for maintaining relationships between people. However, advertising and fraud are also growing incredibly fast and seriously affect our daily life, e.g., leading to money
Jiansu Pu +4 more
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Social Sciences, 2019 Since the turn of the millennium researchers have access to an ever-increasing pool of novel types of video recordings. People use camcorders, mobile phone cameras, and even drones to film and photograph social life, and many public spaces are under ...
Anne Nassauer, Nicolas M. Legewie
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Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Social SciencesHidradenitis suppurativa (HS) is a chronic, inflammatory, and often debilitating skin condition that includes painful “flares” in the groin, genital, and underarms.
Natalie Ingraham +2 more
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Machine Learning and Knowledge Extraction, 2023 Implantable Cardiac Monitor (ICM) devices are demonstrating, as of today, the fastest-growing market for implantable cardiac devices. As such, they are becoming increasingly common in patients for measuring heart electrical activity.
Amnon Bleich +4 more
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FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source