Results 31 to 40 of about 739,559 (311)

Association of Ultrapure Citicoline, Homotaurine and Vitamin E in the Management of Normotensive Glaucoma: A Case Report

Case Reports in Ophthalmology, 2020
Normal tension glaucoma (NTG) remains a therapeutic challenge for the ophthalmologist since there are no effective therapies as the main therapeutic target, i.e., the intraocular pressure (IOP) increase, is missed.
Tommaso Verdina, Nicola Passarelli, Alessandra Carlini, Francesca Chemello, Rodolfo Mastropasqua, Gian Maria Cavallini   +5 more
doaj   +1 more source

Point-wise variability of threshold sensitivity of 24-2 and 10-2 visual fields

Taiwan Journal of Ophthalmology, 2022
PURPOSE: To evaluate point-wise variability of threshold sensitivity at different test locations on 24-2 and 10-2 visual field (VF). MATERIALS AND METHODS: Electronic medical records of patients seen at a tertiary eye care center were screened to include
Aparna Rao, Harsha L Rao, Debananda Padhy   +2 more
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Functional and Morphological Outcomes after Trabeculectomy and Deep Sclerectomy—Results from a Monocentric Registry Study

Diagnostics
The aim of this study was to compare the effectiveness of trabeculectomy (TE) and deep sclerectomy (DS) in lowering intraocular pressure (IOP) and thereby preserving visual field and peripapillary retinal nerve fiber layer (RNFL) tissue in primary open ...
Valentin Pfeiffer, Pascal Aurel Gubser, Xiao Shang, Joel-Benjamin Lincke, Nathanael Urs Häner, Martin Sebastian Zinkernagel, Jan Darius Unterlauft   +6 more
doaj   +1 more source

Development of a Novel Retina−Based Diagnostic Score for Early Detection of Major Depressive Disorder: An Interdisciplinary View

Frontiers in Psychiatry, 2022
BackgroundClinically effective markers for the diagnosis of major depressive disorder (MDD) are lacking. Alterations in retinal features are closely related to the pathophysiological progression of MDD.
Xiao Liu, Shunkai Lai, Shisi Ma, Hong Yang, Lian Liu, Guocheng Yu, Shuming Zhong, Yanbin Jia, Jingxiang Zhong, Jingxiang Zhong   +9 more
doaj   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Interpretable Machine Learning Predictions of Bruch’s Membrane Opening-Minimum Rim Width Using Retinal Nerve Fiber Layer Values and Visual Field Global Indexes

Bioengineering
The aim of this study was to predict Bruch’s membrane opening-minimum rim Width (BMO-MRW), a relatively new parameter using conventional optical coherence tomography (OCT) parameter, using retinal nerve fibre layer (RNFL) thickness and visual field (VF ...
Sat Byul Seo, Hyun-kyung Cho
doaj   +1 more source

Visual field.

Collegium antropologicum, 2013
This article is dedicated to main information about visual field, monocular and binocular ranges of visual field including their defects. Visual field loss may occur to disease of the eye, optic nerve or brain. Typical changes are present at glaucoma and macular degeneration. Visual pathway is also mentioned.
Sokolová Šidlová, Jana, Beneš, Pavel, Holoubková, Zuzana   +2 more
openaire   +3 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Evidence of Asymptomatic Visual Losses after Surgical Repair of Cerebral Aneurysm

Frontiers in Neurology, 2017
Deficits in visual acuity, visual field, and oculomotor function are commonly detected after repair of cerebral aneurysms. However, when these deficits are absent, it does not mean that other potential visual deficits also are absent.
Albedy Moreira Bastos, Albedy Moreira Bastos, Anderson Raiol Rodrigues, Maria Izabel Tentes Côrtes, Eliza Maria da Costa Brito Lacerda, Mônica Gomes Lima, Cláudio Eduardo Corrêa Teixeira, Cláudio Eduardo Corrêa Teixeira, Cláudio Eduardo Corrêa Teixeira, Luiz Carlos de Lima Silveira, Luiz Carlos de Lima Silveira   +10 more
doaj   +1 more source