Results 31 to 40 of about 826,398 (219)

Ex-PRESS Implantation versus Trabeculectomy for Long-Term Maintenance in Patients with Open-Angle Glaucoma

Clinical Ophthalmology, 2023
Kana Tokumo,1 Naoki Okada,1 Hiromitsu Onoe,1 Kaori Komatsu,1 Shun Masuda,1 Hideaki Okumichi,1 Kazuyuki Hirooka,1 Ryo Asaoka,2 Yoshiaki Kiuchi1 1Department of Ophthalmology and Visual Science, Hiroshima University Graduate School of Biomedical Sciences ...
Tokumo K, Okada N, Onoe H, Komatsu K, Masuda S, Okumichi H, Hirooka K, Asaoka R, Kiuchi Y   +8 more
doaj  

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Multimodal Deep Learning Model of Predicting Future Visual Field for Glaucoma Patients

IEEE Access, 2023
Glaucoma is one of the most common reasons for blindness worldwide, especially in elderly people. Glaucoma can be monitored using visual field (VF) tests. Therefore, predicting the future VF to monitor progression of glaucoma is important. In this paper,
Quang T. M. Pham, Jong Chul Han, Do Young Park, Jitae Shin   +3 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Predictive factors for visual prognosis in neurosyphilis presenting with optic atrophy: a Chinese case series study

Frontiers in Neurology
BackgroundWe aimed to explore the clinical features and predictive factors for visual prognosis of neurosyphilis-associated optic atrophy (NSAOA).MethodsThis retrospective observational study included 17 patients (33 eyes) with NSAOA who received ...
Mingjie Zhu, Xin Gu, Pingyu Zhou, Yan Yan   +3 more
doaj   +1 more source

Correlation of central corneal thickness and optic nerve head topography in patients with primary open-angle glaucoma

Oman Journal of Ophthalmology, 2010
Purpose : To evaluate whether changes in optic nerve head topography and visual field in patients with primary open-angle (POAG) are related to central corneal thickness (CCT).
Tharwat H Mokbel, Asaad A Ghanem
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Knowledge and practices of vision screening standards for driving among optometrists in Gauteng province, South Africa

African Vision and Eye Health
Background: Despite the existence of vision screening standards, inconsistent implementation of these standards among optometrists persists. Aim: To evaluate the knowledge and practices of optometrists regarding vision screening standards specific to ...
Gloria T. Tamenti, Tuwani A. Rasengane, Khathutshelo P. Mashige   +2 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source