Results 21 to 30 of about 346,611 (261)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Effects of visual exercises training on developing ball velocity and accuracy shooting of penalty corner in field hockey [PDF]

International Journal of Sports Science and Arts, 2019
The primary aim of this study was, therefore, to investigate the effect of visual training on visual abilities of field hockey female players. A secondary aim was to examine the effect of visual training on velocity of ball shooting in penalty corner of ...
Mohamed Ahmed Badr
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Unexplained Progressive Visual Field Loss in the Presence of Normal Retinotopic Maps

Frontiers in Psychology, 2018
Lesions of primary visual cortex or its primary inputs typically result in retinotopically localized scotomas. Here we present an individual with unexplained visual field loss and deficits in visual perception in the absence of structural damage to the ...
Christina Moutsiana, Christina Moutsiana, Radwa Soliman, Radwa Soliman, Lee de Wit, Merle James-Galton, Martin I. Sereno, Martin I. Sereno, Gordon T. Plant, D. Samuel Schwarzkopf, D. Samuel Schwarzkopf   +10 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Visual neglect in posterior cortical atrophy

BMC Neurology, 2010
Background In posterior cortical atrophy (PCA), there is a progressive impairment of high-level visual functions and parietal damage, which might predict the occurrence of visual neglect. However, neglect may pass undetected if not assessed with specific
Andrade Katia, Samri Dalila, Sarazin Marie, de Souza Leonardo C, Cohen Laurent, de Schotten Michel, Dubois Bruno, Bartolomeo Paolo   +7 more
doaj   +1 more source

visual field tests

JAPANESE ORTHOPTIC JOURNAL, 2003
視能訓練士のかかわることの多い視野検査のskill upのために、検査をすすめる上で大切な点を確認し、検査方法の「コツ」や最新の検査法も含めて下記の項目について報告した。1 検査の準備-輝度調節、眼瞼挙上、屈折矯正2 Goldmann型視野計a.暗点・欠損の検出-中間フィルター使用でのisopter計測、Armaly法とspot checkb.中心の閾値測定-0/1視標と固視標投影器の使用3 自動視野計a.目的に応じたプログラム-測定範囲や視標サイズの変更b.身体障害者手帳申請-自動視野計でのプログラムや閾値検査の応用c.検査結果の解析-視野の経時変化の表示d.検査時間短縮-統計の利用e.自動視野計による新しい検査法-視野異常の極早期発見4 その他の検査-チャート式視野検査、眼底直視下での感度測定 ...
openaire   +2 more sources

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source