Results 91 to 100 of about 1,411,424 (338)

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Does the World Health Organization criterion adequately define glaucoma blindness?

Clinical Ophthalmology, 2017
P Mokhles, JSAG Schouten, HJM Beckers, CAB Webers University Eye Clinic Maastricht, Maastricht, the Netherlands Purpose: Blindness in glaucoma is difficult to assess with merely the use of the current World Health Organization (WHO) definition (a ...
Mokhles P, Schouten JSAG, Beckers HJM, Webers CAB   +3 more
doaj  

Enhancing Oncological Care for India's Aging Population: Addressing the Complex Needs of Older Adults With Cancer

Aging and Cancer, EarlyView.
Aging‐associated physiological and molecular alterations pose significant challenges in cancer management among India's elderly. Limited geriatric oncology expertise, financial constraints, and inadequate specialized care exacerbate disparities. Strategic expansion of insurance coverage, integration of palliative care, and infrastructural advancements ...
Nihanthy D. Sreenath, Mathigatta Shivarudraiah S, Rajath Govind, Kaushik M R   +3 more
wiley   +1 more source

Predicting and Comparing the Subjective Health Experience of Older Cancer Survivors and Non‐Cancer Survivors: A Modeling Approach

Aging and Cancer, EarlyView.
This study underscores the significant influence of frailty and vitality on the subjective health experience of older cancer survivors with acceptance and control emerging as salient mediators. These findings affirm the conceptual and empirical robustness of the model highlighting its potential utility in shaping future interventions for older cancer ...
Damien S. E. Broekharst, Sjaak Bloem, Eline J. Mertens, Nathascha Hanzen, Michel van Agthoven   +4 more
wiley   +1 more source

Reviving the role of optical coherence tomography and visual field analysis as investigative tools for diagnosis of primary open-angle glaucoma in rural tertiary care centre

TNOA Journal of Ophthalmic Science and Research
Background: Glaucoma is the second most common cause of blindness globally and is characterised by raised intraocular pressure, optic disc cupping, and visual field defects.
Mohan Ram Kumar, R Deborah Rinita, Machireddy R Sekhar Reddy, G S Srinivasan   +3 more
doaj   +1 more source

Linking the Laminar Circuits of Visual Cortex to Visual Perception [PDF]

, 2001
A detailed neural model is being developed of how the laminar circuits of visual cortical areas V1 and V2 implement context-sensitive binding processes such as perceptual grouping and attention, and develop and learn in a stable way.
Grossberg, Stephen
core   +1 more source

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source

Visual field examination method using virtual reality glasses compared with the Humphrey perimeter

Clinical Ophthalmology, 2017
Stylianos Tsapakis, Dimitrios Papaconstantinou, Andreas Diagourtas, Konstantinos Droutsas, Konstantinos Andreanos, Marilita M Moschos, Dimitrios Brouzas 1st Department of Ophthalmology, National and Kapodistrian University of Athens, Athens, Greece ...
Tsapakis S, Papaconstantinou D, Diagourtas A, Droutsas K, Andreanos K, Moschos MM, Brouzas D   +6 more
doaj  

A Computational Study Of The Role Of Spatial Receptive Field Structure In Processing Natural And Non-Natural Scenes [PDF]

, 2018
The center-surround receptive field structure, ubiquitous in the visual system, is hypothesized to be evolutionarily advantageous in image processing tasks.
Barranca, Victor J., Zhu, G.
core   +1 more source

Lesion Location and Functional Connections Reveal Cognitive Impairment Networks in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive impairment, fatigue, and depression are common in multiple sclerosis (MS), potentially due to disruption of regional functional connectivity caused by white matter (WM) lesions. We explored whether WM lesions functionally connected to specific brain regions contribute to these MS‐related manifestations.
Alessandro Franceschini, Paolo Preziosa, Paola Valsasina, Damiano Mistri, Monica Margoni, Federica Esposito, Massimo Filippi, Maria A. Rocca   +7 more
wiley   +1 more source