Results 51 to 60 of about 1,411,424 (338)

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

open access: yesMolecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts   +8 more
wiley   +1 more source

Adding Genetics to the Risk Factors Model Improved Accuracy for Detecting Visual Field Progression in Newly Diagnosed Exfoliation Glaucoma Patients

open access: yesBiomedicines
Background: This study aims to determine whether including genetics as a risk factor for progression will improve the accuracy of the models used in newly diagnosed exfoliation glaucoma patients. Methods: This was a prospective cohort study.
Marcelo Ayala
doaj   +1 more source

Visual acuity after trabeculectomy [PDF]

open access: yesVojnosanitetski Pregled, 2005
Background/Aim. In this study we compared the two groups of glaucoma patients who had underwent trabeculectomy, with or without intraoperative application of antimetabolite 5-Fluorouracile (5 FU). Methods. We followed up 50 glaucoma patients (group I) in
Buzarovska-Blaževska Karolina   +3 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Visual functions and their association with road traffic accidents among vehicle drivers in Gauteng

open access: yesAfrican Vision and Eye Health
Background: South Africa has a high mortality rate because of road traffic accidents (RTAs) compared to other countries. Aim: To determine the visual functions and their association with the occurrence of RTAs among vehicle drivers in the Gauteng ...
Gloria T. Tamenti   +2 more
doaj   +1 more source

Acute Macular Neuroretinopathy Presenting as Bitemporal Defects on Humphrey Visual Field

open access: yesVision Pan-America, 2016
A 25-year-old woman presented with blurry vision, headache, nausea, and syncope. Humphrey visual field testing revealed bitemporal defects, but magnetic resonance imaging was negative for chiasmal pathology.
Rachel Mogil   +3 more
doaj   +1 more source

Tolosa-Hunt Syndrome in a Young Subject

open access: yesDelhi Journal of Ophthalmology, 2022
Tolosa-Hunt syndrome (THS) is a non-specific inflammation of the cavernous sinus or superior orbital fissure which causes painful, usually unilateral ophthalmoparesis or ophthalmoplegia. A 22-year-old lady presented with diminution of vision, pain in her
Rajiv Garg   +3 more
doaj   +1 more source

Local processing in neurites of VGluT3- expressing amacrine cells differentially organizes visual information [PDF]

open access: yes, 2017
Neurons receive synaptic inputs on extensive neurite arbors. How information is organized across arbors and how local processing in neurites contributes to circuit function is mostly unknown.
Amthor   +54 more
core   +2 more sources

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

open access: yesMolecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad   +12 more
wiley   +1 more source

“VisualFields Easy”: an iPad Application as a Simple Tool for Detecting Visual Field Defects

open access: yesPhilippine Journal of Ophthalmology, 2016
Purpose/Objective: This study aims to determine the reliability of the “VisualFields Easy” application in detecting visual field loss among ophthalmology patients; and to determine the sensitivity, specificity, positive predictive and negative predictive
Angelane S. Santos, MD   +1 more
doaj  

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