Results 51 to 60 of about 352,043 (365)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Visual fields interpretation in glaucoma: a focus on static automated perimetry [PDF]

, 2013
Examining the visual fields is an integral part of any ophthalmic ...
Moustafa Yaqub
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Visual Field

Collegium antropologicum, 2013
This article is dedicated to main information about visual field, monocular and binocular ranges of visual field including their defects. Visual field loss may occur to disease of the eye, optic nerve or brain. Typical changes are present at glaucoma and macular degeneration. Visual pathway is also mentioned.
Sokolová Šidlová, Jana, Beneš, Pavel, Holoubková, Zuzana   +2 more
openaire   +3 more sources

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Measurement of the hypotenuse of the vertical optic nerve head cup with spectral-domain optical coherence tomography for the structural diagnosis of glaucoma

Clinical Ophthalmology, 2018
Fabio Lavinsky,1,2 Camila Zanella Benfica,2 Nédio Castoldi,2 Anne Elise Cruz do Carmo Chaves,2 Paulo Augusto de Arruda Mello1 1Department of Ophthalmology, Paulista School of Medicine, São Paulo Hospital, Universidade Federal de São
Lavinsky F, Benfica CZ, Castoldi N, Cruz do Carmo Chaves AE, Mello PAA   +4 more
doaj  

Correlation of diurnal fluctuations in intraocular pressure and progression of chronic simple glaucoma

Kerala Journal of Ophthalmology
Purpose: To study the correlation between diurnal fluctuations of intraocular pressure and progression of chronic simple glaucoma. Introduction: Out of all the risk factors for glaucoma, only modifiable risk factor is intraocular pressure.
Noorjahan Sajid, Priyangee Sen, Shoeb Mohd, Shrishti Ahuja   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Adding Genetics to the Risk Factors Model Improved Accuracy for Detecting Visual Field Progression in Newly Diagnosed Exfoliation Glaucoma Patients

Biomedicines
Background: This study aims to determine whether including genetics as a risk factor for progression will improve the accuracy of the models used in newly diagnosed exfoliation glaucoma patients. Methods: This was a prospective cohort study.
Marcelo Ayala
doaj   +1 more source

Study of Optimal Perimetric Testing In Children (OPTIC): Normative visual field values in children

, 2015
Purpose: We sought to define normative visual field (VF) values for children using common clinical test protocols for kinetic and static perimetry. Design: Prospective, observational study.
Cortina-Borja, M, Cortina-Borja, Mario, Walters, BC, Patel, Dipesh E., Cumberland, PM, Patel, DE, Cumberland, Phillippa M., Walters, Bronwen C., Rahi, Jugnoo S., Russell-Eggitt, I, Russell-Eggitt, Isabelle, Rahi, JS   +11 more
core   +1 more source