Results 81 to 90 of about 2,543,865 (291)

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

The neural correlates of visual imagery vividness - An fMRI study and literature review.

open access: yesCortex; a journal devoted to the study of the nervous system and behavior, 2017
Using the Vividness of Visual Imagery Questionnaire we selected 14 high-scoring and 15 low-scoring healthy participants from an initial sample of 111 undergraduates.
J. Fulford   +6 more
semanticscholar   +1 more source

The Role of Visual Imagery in Spelling

open access: yesBrain and Language, 1996
Current models of spelling posit that information from the orthographic output buffer can be translated into physical letter codes for written output or into name letter codes for spoken output. It is not known, at present, whether or not visualization of these codes is necessary to spell or recognize orally spelled words. We report a 73-year-old woman
Department of Neurology, University of Cincinnati Medical Center, Cincinnati, Ohio ( host institution )   +3 more
openaire   +3 more sources

Presence in Visual Mental Imagery [PDF]

open access: yes, 2013
'Presence', the sense of being inside a virtual environment evoked with the help of computer mediation, has come to be a subject well explored in the field of virtual reality. Studies on mental imagery confirm that we can intuitively evoke objects and spaces in our minds and interact with them temporally.
Jayesh S. Pillai   +3 more
openaire   +4 more sources

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

open access: yesMolecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder   +10 more
wiley   +1 more source

Visual imagery during real-time fMRI neurofeedback from occipital and superior parietal cortex

open access: yesNeuroImage, 2019
Visual imagery has been suggested to recruit occipital cortex via feedback projections from fronto-parietal regions, suggesting that these feedback projections might be exploited to boost recruitment of occipital cortex by means of real-time ...
P. Andersson, F. Ragni, A. Lingnau
semanticscholar   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Attending to Visual Stimuli versus Performing Visual Imagery as a Control Strategy for EEG-based Brain-Computer Interfaces

open access: yesScientific Reports, 2018
Currently the most common imagery task used in Brain-Computer Interfaces (BCIs) is motor imagery, asking a user to imagine moving a part of the body. This study investigates the possibility to build BCIs based on another kind of mental imagery, namely ...
Nataliya Kosmyna   +2 more
semanticscholar   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Differential temporal dynamics during visual imagery and perception

open access: yesbioRxiv, 2017
Visual perception and imagery rely on similar representations in the visual cortex. During perception, visual activity is characterized by distinct processing stages, but the temporal dynamics underlying imagery remain unclear.
N. Dijkstra   +4 more
semanticscholar   +1 more source

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