Results 1 to 10 of about 401,751 (264)

Involvement of the MEK-ERK/p38-CREB/c-fos signaling pathway in Kir channel inhibition-induced rat retinal Müller cell gliosis

open access: yesScientific Reports, 2017
Our previous studies have demonstrated that activation of group I metabotropic glutamate receptors downregulated Kir channels in chronic ocular hypertension (COH) rats, thus contributing to Müller cell gliosis, characterized by upregulated expression of ...
Feng Gao   +9 more
doaj   +1 more source

En face optical coherence tomography detection of Schlemm’s canal in primary open angle glaucoma

open access: yesFrontiers in Physiology, 2023
Purpose: To compare the morphological characteristics of Schlemm’s canal (SC) in patients with primary open-angle glaucoma (POAG) and healthy controls, using swept-source optical coherence tomography (SS-OCT) with en face reconstruction.Methods: In this ...
Haili Huang   +8 more
doaj   +1 more source

Nerve growth factor inhibits TLR3-induced inflammatory cascades in human corneal epithelial cells

open access: yesJournal of Inflammation, 2019
Background In herpes simplex epithelial keratitis, excessive TLR3-induced cellular responses after virus infection evoke inflammatory cascades that might be destructive to the host cornea. Nerve growth factor (NGF), a pluripotent neurotrophic factor with
Huiyu Chen   +3 more
doaj   +1 more source

Evaluation of axial length/total corneal refractive power ratio as a potential marker for ocular diagnosis of Marfan’s syndrome in children [PDF]

open access: yesInternational Journal of Ophthalmology, 2021
AIM: To investigate whether the axial length (AL)/total corneal refractive power (TCRP) ratio is a sensitive and simple factor that can be used for the early diagnosis of Marfan's syndrome (MFS) in children.
Tian-Hui Chen   +8 more
doaj   +1 more source

Scleral ultrastructure and biomechanical changes in rabbits after negative lens application [PDF]

open access: yesInternational Journal of Ophthalmology, 2018
AIM: To address the microstructure and biomechanical changes of the sclera of rabbits after negative lens application by spectacle frame apparatus. METHODS: Five New Zealand rabbits of seven weeks post-natal were treated with -8 D lens monocularly over ...
Xiao Lin   +8 more
doaj   +1 more source

Metabolomic Profiling of Aqueous Humor and Plasma in Primary Open Angle Glaucoma Patients Points Towards Novel Diagnostic and Therapeutic Strategy

open access: yesFrontiers in Pharmacology, 2021
Glaucoma is the second leading cause of blindness globally characterized by progressive loss of retinal ganglion cells (RGCs) and irreversible visual deficiency.
Yizhen Tang   +16 more
doaj   +1 more source

Novel Mutations Associated With Various Types of Corneal Dystrophies in a Han Chinese Population

open access: yesFrontiers in Genetics, 2019
Aims: To study the genetic spectra of corneal dystrophies (CDs) in Han Chinese patients using next-generation sequencing (NGS).Methods: NGS-based targeted region sequencing was performed to evaluate 71 CD patients of Han Chinese ethnicity.
Jing Zhang   +20 more
doaj   +1 more source

Measurement of the depths at different regions of the anterior chamber in healthy Chinese adults [PDF]

open access: yesInternational Journal of Ophthalmology, 2020
AIM: To measure the depths of different regions of the anterior chamber (AC) in healthy Chinese adults, and to explore possible correlations with age or gender.
Yuan Zong   +5 more
doaj   +1 more source

Novel Mutations in COL6A3 That Associated With Peters’ Anomaly Caused Abnormal Intracellular Protein Retention and Decreased Cellular Resistance to Oxidative Stress

open access: yesFrontiers in Cell and Developmental Biology, 2020
Peters’ anomaly (PA) is a rare form of anterior segment dysgenesis characterized by central corneal opacity accompanied by iridocorneal or lenticulo-corneal adhesions.
Yue Li   +14 more
doaj   +1 more source

A novel PAX2 heterozygous mutation in a family with Papillorenal syndrome: A case report and review of the literature

open access: yesAmerican Journal of Ophthalmology Case Reports, 2021
Purpose: Papillorenal syndrome (PAPRS) is a rare inherited disorder often involves abnormalities of eye and kidney. Paired box 2 (PAX2) gene, which is widely expressed in the development of the organs including kidney, ureter, eye, ear, and central ...
Shixue Liu   +3 more
doaj   +1 more source

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