Results 91 to 100 of about 4,218,690 (285)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Using audio and visual information for single channel speaker separation [PDF]
, 2015 This work proposes a method to exploit both audio and vi- sual speech information to extract a target speaker from a mix- ture of competing speakers. The work begins by taking an ef- fective audio-only method of speaker separation, namely the soft mask ...
Khan, Faheem, Milner, Ben
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Perception and control of rotorcraft flight [PDF]
Three topics which can be applied to rotorcraft flight are examined: (1) the nature of visual information; (2) what visual information is informative about; and (3) the control of visual information.
Owen, Dean H.
core +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Information-Based Social Coordination Between Players of Different Skill in Doubles Pong
Frontiers in Psychology, 2018 We studied how teams of two players of different skill level intercepted approaching balls in the doubles-pong task. In this task, the two players moved their on-screen paddles along a shared interception axis, so that the approaching ball was ...
A. A. M. (Daphne) van Opstal +5 more
doaj +1 more source
NKCC1: A key regulator of glioblastoma progression
Molecular Oncology, EarlyView.Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen +5 more
wiley +1 more source
Distance sonification in image-guided neurosurgery
Healthcare Technology Letters, 2017 Image-guided neurosurgery, or neuronavigation, has been used to visualise the location of a surgical probe by mapping the probe location to pre-operative models of a patient's anatomy.
Joseph Plazak +3 more
doaj +1 more source
Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276
FEBS Open Bio, EarlyView.Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig +7 more
wiley +1 more source
Decoding the activity of neuronal populations in macaque primary visual cortex [PDF]
, 2011 Visual function depends on the accuracy of signals carried by visual cortical neurons. Combining information across neurons should improve this accuracy because single neuron activity is variable.
Graf, Arnulf B. A. +3 more
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