Results 71 to 80 of about 4,210,540 (287)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Application of Stereo-Imaging Technology to Medical Field [PDF]

Healthcare Informatics Research, 2012
ObjectivesThere has been continuous development in the area of stereoscopic medical imaging devices, and many stereoscopic imaging devices have been realized and applied in the medical field.
Kyoung Won Nam, Jeongyun Park, In Young Kim, Kwang Gi Kim   +3 more
doaj   +1 more source

Improving Visual Field Examination of the Macula Using Structural Information [PDF]

, 2018
Purpose: To investigate a novel approach for structure-function modeling in glaucoma to improve visual field testing in the macula. Methods: We acquired data from the macular region in 20 healthy eyes and 31 with central glaucomatous damage.
Allegrini, D., Crabb, D. P., Montesano, G., Romano, M. R., Rossetti, L. M.   +4 more
core   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

What visual information is used for stereoscopic depth displacement discrimination? [PDF]

, 2012
There are two ways to detect a displacement in stereoscopic depth, namely by monitoring the change in disparity over time (CDOT) or by monitoring the inter-ocular velocity difference (IOVD).
Harris, Julie, Nefs, Harold
core   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

AI nutrition recommendation using a deep generative model and ChatGPT

Scientific Reports
In recent years, major advances in artificial intelligence (AI) have led to the development of powerful AI systems for use in the field of nutrition in order to enhance personalized dietary recommendations and improve overall health and well-being ...
Ilias Papastratis, Dimitrios Konstantinidis, Petros Daras, Kosmas Dimitropoulos   +3 more
doaj   +1 more source

Distortions of Subjective Time Perception Within and Across Senses [PDF]

, 2008
Background: The ability to estimate the passage of time is of fundamental importance for perceptual and cognitive processes. One experience of time is the perception of duration, which is not isomorphic to physical duration and can be distorted by a ...
A Bendixen, A Johnston, A Pascual-Leone, BA Wright, D Alais, D Brainard, D Buonomano, D Burr, D Pelli, D Rose, D Zakay, David Eagleman, Dean V. Buonomano, DM Eagleman, DW Massaro, E Pöppel, E Pöppel, G Oléron, G Westheimer, GH Recanzone, I Hodinott-Hill, J Bresciani, J Gebhard, J Park, J Ross, JH Wearden, JT Coull, JT Coull, JX Maier, K N'Diaye, K Watanabe, K Yarrow, K Yarrow, KP Kording, L Allan, L Battelli, L Shams, Ladan Shams, M Dhamala, M Treisman, M Wittmann, MC Morrone, MD Mauk, MI Leon, MJ Penner, MO Ernst, MO Ernst, N Roach, P Fraisse, PA Lewis, PU Tse, R Efron, R Kanai, R Plomp, R van Beers, R Welch, RA Block, RB Ivry, S Denève, S Droit-Volet, S Droit-Volet, S Goldstone, SE Guttman, Shinsuke Shimojo, SK Rosahl, SL Franconeri, SL Franconeri, SS Nagarajan, T Shipley, TB Penney, TB Penney, UR Karmarkar, UR Karmarkar, V Pariyadath, V van Wassenhove, Virginie van Wassenhove, W Ball, W James, W Schiff   +78 more
core   +7 more sources

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source