Results 91 to 100 of about 176,532 (310)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Adaptive visual sampling

, 2010
PhDVarious visual tasks may be analysed in the context of sampling from the visual field. In visual psychophysics, human visual sampling strategies have often been shown at a high-level to be driven by various information and resource related factors ...
Raja, Yogesh
core  

Stimulus localization interferes with stimulus recognition: Evidence from an attentional blink paradigm

, 2013
Griffiths G, Herwig A, Schneider WX. Stimulus localization interferes with stimulus recognition: Evidence from an attentional blink paradigm. Journal of Vision.
Schneider, Werner X., Griffiths, Gordian, Herwig, Arvid ; https://orcid.org/   +2 more
core   +1 more source

Finding and recognising objects in natural scenes: complementary computations in the dorsal and ventral visual systems [PDF]

, 2014
Searching for and recognising objects in complex natural scenes is implemented by multiple saccades until the eyes reach within the reduced receptive field sizes of inferior temporal cortex (IT) neurons.
Edmund T. Rolls, Tristan J. Webb, Webb, Tristan J., Rolls, Edmund T., Tristan James Webb, Edmund eRolls   +5 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

ADCT: Improving Robustness and Calibration of Pattern Recognition Models Against Visual Illusions

Applied Sciences
Perception-level interference patterns, such as abutting gratings that induce illusory contours and pseudoisochromatic dot camouflage, can trigger failures that are not well captured by conventional corruption benchmarks.
Hui Dong, Lin Yu, Yi Yang
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Designing a resource-allocating codebook for patch-based visual object recognition

, 2010
The state-of-the-art approach in visual object recognition is the use of local information extracted at several points or image patches from an image. Local information at specific points can deal with object shape variability and partial occlusions. The
Ramanan, Amirthalingam
core  

Non-sparse linear representations for visual tracking with online reservoir metric learning [PDF]

, 2012
Most sparse linear representation-based trackers need to solve a computationally expensive ℓ₁-regularized optimization problem. To address this problem, we propose a visual tracker based on non-sparse linear representations, which admit an efficient ...
Qinfeng Shi, Van Den Hengel, A., Xi Li, A. Dick, Shen, C., Dick, A., A. van den Hengel, Chunhua Shen, Li, X., Shi, Q.   +9 more
core   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source