Results 61 to 70 of about 176,532 (310)

Interpretation of pharmacokinetic data in preclinical studies of new drugs. Single intravenous administration

open access: yesФармакокинетика и Фармакодинамика, 2022
Review. Further development of the methodological level of the decision support system proposed for the organization of primary selection and experimental preclinical study of new drugs.
S. V. Geodakyan
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Distinct multisensory perceptual processes guide enhanced auditory recognition memory in older cochlear implant users

open access: yesNeuroImage: Clinical, 2022
In naturalistic situations, sounds are often perceived in conjunction with matching visual impressions. For example, we see and hear the neighbor’s dog barking in the garden. Still, there is a good chance that we recognize the neighbor’s dog even when we
Jan-Ole Radecke   +5 more
doaj   +1 more source

A generalized probabilistic framework for compact codebook creation [PDF]

open access: yes, 2011
Appearing in IEEE Conf. Comp. Vis. Pattern Recogn. 2011. This reprint differs from the original in pagination and typographic detailCompact and discriminative visual codebooks are pre-ferred in many visual recognition tasks.
Shen, Chunhua   +8 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

Growing semantically meaningful models for visual SLAM

open access: yes, 2010
Though modern Visual Simultaneous Localisation and Mapping (vSLAM) systems are capable of localising robustly and efficiently even in the case of a monocular camera, the maps produced are typically sparse point-clouds that are difficult to interpret and ...
Flint, A.   +12 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

PATTERN RECOGNITION METHODS IN CASE OF VISUAL INFORMATION SEMANTIC INTEGRITY VIOLATIONS

open access: yesНаучно-технический вестник информационных технологий, механики и оптики, 2018
We consider computer vision issues with a view to embed it into vehicles and automate the traffic process by detecting of objects and road users. Three basic stages of pattern recognition in the image are enumerated: image preparation for analysis ...
Kim I.V, Matveeva A.A, Viksnin I.I.
doaj   +1 more source

Deformation-specific and deformation-invariant visual object recognition: pose vs identity recognition of people and deforming objects [PDF]

open access: yes, 2014
When we see a human sitting down, standing up, or walking, we can recognise one of these poses independently of the individual, or we can recognise the individual person, independently of the pose. The same issues arise for deforming objects. For example,
Tristan J Webb   +5 more
core   +1 more source

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